Immunohistochemistry of paraffin-embedded human ovarian cancer using NOD2 Antibody at dilution of 1:100

NOD2 / CARD15 Antibody

Antibody:	Rabbit Polyclonal
Applications:	Enzyme-Linked Immunosorbent Assay, Immunofluorescence, Immunohistochemistry (general)
Reactivity:	Human
Format:	Liquid

$300.00each

Catalog Number: LS-C501911-50

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Description: CARD15 antibody LS-C501911 is an unconjugated rabbit polyclonal antibody to human CARD15 (NOD2). Validated for ELISA, IF and IHC.
Application: ELISA, IF, IHC
Reactivity: Hu
Intended Use: Research Use Only
Guarantees: This antibody carries the LSBio 100% Guarantee. ✓
Category: Antibodies > Primary Antibodies > Polyclonal Antibodies
Alternative Names: BLAU | CARD15 | ACUG | NOD-like receptor C2 | NOD2B | NLRC2 | IBD1 | NOD2 | CLR16.3 | PSORAS1
UniProt Number: Q9HC29
NCBI GenBank: NM_022162 | NP_071445.1
SwissProt: Q9HC29

Target: Human NOD2 / CARD15
Antigen Species: Human
Epitope: Involved in gastrointestinal immunity. Upon stimulation by muramyl dipeptide (MDP), a fragment of bacterial peptidoglycan, binds the proximal adapter receptor-interacting RIPK2, which recruits ubiquitin ligases as XIAP, BIRC2, BIRC3 and the LUBAC complex, triggering activation of MAP kinases and activation of NF-kappa-B signaling. This in turn leads to the transcriptional activation of hundreds of genes involved in immune response. Required for MDP-induced NLRP1-dependent CASP1 activation and IL1B release in macrophages (PubMed:18511561).
Gene Name: NOD2

Immunogen: Recombinant Human Nucleotide-binding oligomerization domain-containing protein 2 protein (460-733AA)
Immunogen Type: Recombinant Immunogen

Storage Conditions: Short term: -20°C; Long term: -80°C; Avoid freeze-thaw cycles.
Recommended Storage Buffer: PBS

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