LSBio
Monoclonal Rat anti-Mouse HAVCR1 / KIM-1 Antibody (clone RMT1-10, IF)

TIM-1 transfected NRK cells stained with Rat anti-Mouse TIM-1. This image was taken for the unmodified form of this product. Other forms have not been tested.

Monoclonal Rat anti-Mouse HAVCR1 / KIM-1 Antibody (clone RMT1-10, IF)

Primary AntibodyLSBio Guarantee
Antibody:Rat Monoclonal
Applications:Enzyme-Linked Immunosorbent Assay, Flow Cytometry, Immunofluorescence
Reactivity:Mouse
Format:Liquid
See all Mouse HAVCR1 / KIM-1 Antibodies →
$286.00each
Catalog Number: LS-C187571-0.1

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Overview

Description
KIM-1 antibody LS-C187571 is an unconjugated rat monoclonal antibody to mouse KIM-1 (HAVCR1). Validated for ELISA, Flow and IF.
Application
ELISA, FC, IF
Reactivity
Ms
Intended Use
RUO
Guarantees
This antibody carries the LSBio 100% Guarantee. ✓
Category
Antibodies > Primary Antibodies > Monoclonal Antibodies
Alternative Names
HAVCR-1 | HAVCR1 | KIM-1 | Kidney injury molecule 1 | KIM1 | T-cell membrane protein 1 | TIM1 | TIMD1 | TIM-1 | HAVCR | TIMD-1 | CD365
UniProt Number
Q96D42
NCBI GenBank
NM_012206, NP_036338.2
SwissProt
Q96D42

Target

Target
Mouse HAVCR1 / KIM-1
Antigen Species
Ms
Epitope
Clone RMT1-10 specifically recognizes mouse Tim-1 (T-cell immunoglobulin mucin 1), a cell surface glycoprotein and member of the immunoglobulin superfamily, which was first identified as the hepatitis A virus cellular receptor (HAVCR), and is highly expressed in the liver (isoform Tim-1a) and the kidneys (isoform Tim-1b). Tim-1 is highly expressed by activated CD4+ T cells, and acts as a positive/negative co-stimulatory molecule of T cell proliferation, cytokine production and tolerance abrogation, and is the receptor for Tim-4, expressed on APCs. Tim-1 expression is greater on Th2 than Th1 cells, and studies have shown that interaction between Tim-1 on Th2 cells and Tim-4 on dendritic cells (DCs), enhances Th2 cell function, and have implicated Tim-1 as a critical player in the development of atopic disease, and in particular airway hypersensitivity. Polymorphic forms of Tim-1 are associated with increased susceptibility to asthma, eczema and Rheumatoid arthritis. Clone RMT1-10 has been shown to promote Th2 responses, and inhibit antigen-specific T cell proliferation, in contrast to the agonistic function of many Tim-1 antibodies see for details. Clone RMT1-10 has been shown to reduce the severity of EAE (experimental autoimmune encephalomyelitis) and delay disease onset, in mice studies see for details.
Gene Name
HAVCR1

Antibody

Host Species
Rt
Clonality
Monoclonal
Clone
RMT1-10
Isotype
IgG2a

Immunogen

Immunogen
Full-length mouse Tim-1-Ig, containing both the IgV and mucin domains of Tim-1.

Format

Conjugate/Label
Unconj
Format
Liquid
Formulation
PBS, 0.09% Sodium Azide
Concentration
1 mg/mL
Preservative
Yes
Purification Method
Prot G

Storage & Handling

Storage Conditions
Store at 4°C or at -20°C. Store undiluted. Avoid freeze-thaw cycles. Microcentrifugation recommended if solution contains precipitate.
Recommended Storage Buffer
PBS

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