TIM-1 transfected NRK cells stained with Rat anti-Mouse TIM-1. This image was taken for the unmodified form of this product. Other forms have not been tested.
HAVCR1 / KIM-1 Antibody (clone RMT1-10, RPE)
Primary AntibodyLSBio Guarantee
| Antibody: | Rat Monoclonal |
| Applications: | Flow Cytometry |
| Reactivity: | Mouse |
| Format: | Lyophilized |
$413.00each
Catalog Number: LS-C187572-100
Catalog Number: LS-C187572
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- Description
- KIM-1 antibody LS-C187572 is an RPE-conjugated rat monoclonal antibody to mouse KIM-1 (HAVCR1). Validated for Flow.
- Application
- FC
- Reactivity
- Ms
- Intended Use
- Research Use Only
- Guarantees
- This antibody carries the LSBio 100% Guarantee. ✓
- Category
- Antibodies > Primary Antibodies > Monoclonal Antibodies
- Alternative Names
- HAVCR-1 | HAVCR1 | KIM-1 | Kidney injury molecule 1 | KIM1 | T-cell membrane protein 1 | TIM1 | TIMD1 | TIM-1 | HAVCR | TIMD-1 | CD365
- UniProt Number
- Q96D42
- NCBI GenBank
- NM_012206 | NP_036338.2
- SwissProt
- Q96D42
Target
- Target
- Mouse HAVCR1 / KIM-1
- Antigen Species
- Mouse
- Epitope
- Clone RMT1-10 specifically recognizes mouse Tim-1 (T-cell immunoglobulin mucin 1), a cell surface glycoprotein and member of the immunoglobulin superfamily, which was first identified as the hepatitis A virus cellular receptor (HAVCR), and is highly expressed in the liver (isoform Tim-1a) and the kidneys (isoform Tim-1b). Tim-1 is highly expressed by activated CD4+ T cells, and acts as a positive/negative co-stimulatory molecule of T cell proliferation, cytokine production and tolerance abrogation, and is the receptor for Tim-4, expressed on APCs. Tim-1 expression is greater on Th2 than Th1 cells, and studies have shown that interaction between Tim-1 on Th2 cells and Tim-4 on dendritic cells (DCs), enhances Th2 cell function, and have implicated Tim-1 as a critical player in the development of atopic disease, and in particular airway hypersensitivity. Polymorphic forms of Tim-1 are associated with increased susceptibility to asthma, eczema and Rheumatoid arthritis. Clone RMT1-10 has been shown to promote Th2 responses, and inhibit antigen-specific T cell proliferation, in contrast to the agonistic function of many Tim-1 antibodies see for details. Clone RMT1-10 has been shown to reduce the severity of EAE (experimental autoimmune encephalomyelitis) and delay disease onset, in mice studies see for details.
- Gene Name
- HAVCR1
Antibody
- Host Species
- Rat
- Clonality
- Monoclonal
- Clone
- RMT1-10
- Isotype
- IgG2a
Immunogen
- Immunogen
- Full-length mouse Tim-1-Ig, containing both the IgV and mucin domains of Tim-1.
Format
- Conjugate/Label
- Phycoerythrin
- Format
- Lyophilized
- Formulation
- PBS, 0.09% Sodium Azide, 5% Sucrose, 1% BSA
- Preservative
- Yes
- Purification Method
- Protein G Affinity
Storage & Handling
- Storage Conditions
- Store at 4°C. Do not freeze. Store undiluted. Protect from light. Microcentrifugation recommended if solution contains precipitate.
- Recommended Storage Buffer
- PBS