Monoclonal Rat anti-Mouse CD90.2 (Mouse) Antibody (clone 30H12, AF647)
Catalog Number: LS-C810655
2 sizes / from $259.00
Antibody: Rat Monoclonal
Applications: Flow Cytometry
Reactivity: Mouse
Format: Liquid
Monoclonal Mouse anti-Human ABCB1 / MDR1 / P Glycoprotein Antibody (clone UIC2, IHC, IF)
Primary AntibodyLSBio Guarantee
| Antibody: | Mouse Monoclonal |
| Applications: | Flow Cytometry, Immunofluorescence, Immunohistochemistry (general), Immunohistochemistry, Frozen, Immunohistochemistry, Paraffin, Immunoprecipitation |
| Reactivity: | Human |
| Format: | Liquid |
$286.00each
Catalog Number: LS-C58240-0.1
Catalog Number: LS-C58240
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- Description
- P Glycoprotein antibody LS-C58240 is an unconjugated mouse monoclonal antibody to human P Glycoprotein (ABCB1 / MDR1). Validated for Flow, IF, IHC and IP. Cited in 1 publication.
- Application
- FC, IF, IHC, IHC-F, IHC-P, IP
- Reactivity
- Hu
- Nonreactive Species
- Mouse, Rat
- Intended Use
- Research Use Only
- Guarantees
- This antibody carries the LSBio 100% Guarantee. ✓
- Category
- Antibodies > Primary Antibodies > Monoclonal Antibodies
- Alternative Names
- ABC20 | ABCB1 | Abcb1b | CLCS | Colchicin sensitivity | CD243 | IBD13 | gp170 | MDR1 | Multidrug resistance protein 1 | P glycoprotein | P-glycoprotein 1 | P-GP | CD243 antigen | PGY1
- Recommended Dilution: FC
- 1:50 - 1:200
- UniProt Number
- P08183
- NCBI GenBank
- NM_000927 | NP_000918.2
- SwissProt
- P08183
Target
- Target
- Human ABCB1 / MDR1 / P Glycoprotein
- Antigen Species
- Human
- Epitope
- Recognizes an extracellular conformational epitope of CD243, also known as MDR1 (multi-drug resistance protein 1) and Pgp (P-glycoprotein), a transmembrane protein and member of the ABC transporter (ATP-binding cassette) family, which acts as an active efflux pump for a diverse range of lipophillic compounds. CD243 is expressed at low levels in the cell membrane of peripheral blood leucocytes, and constitutively expressed on the apical plasma membrane of excretory epithelial cells of the kidney, liver, brain and small intestine. Strong inhibitor of CD243-mediated efflux and of the resistance of MDR cells to CD243 transported cytotoxic drugs. Can be used in a shift assay to selectively demonstrate the expression and functional activity of CD243 in a target cell. Does not cross-react with mitochondrial pyruvate carboxylase.
- Gene Name
- ABCB1
Antibody
- Host Species
- Mouse
- Clonality
- Monoclonal
- Clone
- UIC2
- Isotype
- IgG2a
Immunogen
- Immunogen
- Mouse Balb/c 3T3 fibroblasts transfected with human CD243 cDNA.
- Immunogen Type
- DNA Immunization
Format
- Conjugate/Label
- Unconjugated
- Format
- Liquid
- Formulation
- PBS, 0.09% Sodium Azide
- Concentration
- 1 mg/mL
- Preservative
- Yes
- Purification Method
- Affinity Purified
Storage & Handling
- Storage Conditions
- Store at 4°C or at -20°C. Store undiluted. Avoid freeze-thaw cycles. Microcentrifugation recommended if solution contains precipitate.
- Recommended Storage Buffer
- PBS
Prognostic significance of miR-23b in combination with P-gp, MRP and LRP/MVP expression in non-small cell lung cancer. M Janikova, V Zizkova, J Skarda, G Kharaishvili, L Radova, Z Kolar. Neoplasma. 2016 June;63:576-87. PubMed: 27268921
