LSBio
IHC-plus™ Polyclonal Goat anti-Human GPX4 / MCSP Antibody (aa184-196, IHC, WB)

Anti-GPX4 antibody IHC of human testis. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.

IHC-plus™ Polyclonal Goat anti-Human GPX4 / MCSP Antibody (aa184-196, IHC, WB)

Primary AntibodyLSBio Guarantee
Antibody:Goat Polyclonal
Applications:Enzyme-Linked Immunosorbent Assay, Immunohistochemistry (general), Immunohistochemistry, Paraffin, Western Blot
Reactivity:Human, Non-Human Primate
Format:Liquid
See all GPX4 / MCSP antibodies →
$495.00each
Catalog Number: LS-B3246-50

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Overview

Description
MCSP antibody LS-B3246 is an unconjugated goat polyclonal antibody to MCSP (GPX4) (aa184-196) from human. It is reactive with human and monkey. Validated for IHC, Peptide-ELISA and WB. Tested on 20 paraffin-embedded human tissues. Cited in 2 publications.
Application
ELISA, IHC, IHC-P, WB
Reactivity
Hu, NHP
Intended Use
Research Use Only
Guarantees
This product carries the LSBio 100% Guarantee.
Category
Antibodies > Primary Antibodies > Polyclonal Antibodies
Alternative Names
GPX4 | GPx-4 | MCSP | SnPHGPx | Phospholipid hydroperoxidase | SnGPx | Glutathione peroxidase 4 | GSHPx-4 | PHGPx
Recommended Dilution: IHC-P
2.5 µg/ml
Recommended Dilution: WB
0.1 - 0.3 µg/ml
UniProt Number
P36969
SwissProt
P36969

Target

Target
GPX4 / MCSP
Antigen Species
Human
Specificity
Human GPX4. This antibody is expected to recognise isoform A (NP_002076.2) and isoform C (NP_001034937.1).
Epitope
Human GPX4. This antibody is expected to recognise isoform A (NP_002076.2) and isoform C (NP_001034937.1).
Gene Name
GPX4

Antibody

Host Species
Goat
Clonality
Polyclonal
Origin Species
Human

Immunogen

Immunogen
Peptide with sequence C-EEPLVIEKDLPHY, from the C-Terminus of protein sequence according to NP_002076.2NP_001034937.1.
Immunogen Type
Peptide

Format

Conjugate/Label
Unconjugated
Format
Liquid
Formulation
TBS, pH 7.3, 0.02% Sodium Azide, 0.5% BSA
Concentration
0.5 mg/mL
Animal Free
No
Carrier-Free
No
Preservative
Yes
Purification Method
Ammonium Sulfate Precipitation

Storage & Handling

Storage Conditions
Aliquot and store at -20°C. Avoid freeze-thaw cycles.
Recommended Storage Buffer
TBS

SECIS-binding protein 2 promotes cell survival by protecting against oxidative stress. Papp LV, Lu J, Bolderson E, Boucher D, Singh R, Holmgren A, Khanna KK. Antioxidants & redox signaling. 2010;12:797-808.

PubMed: 19803747


Mutations in the selenocysteine insertion sequence-binding protein 2 gene lead to a multisystem selenoprotein deficiency disorder in humans. Schoenmakers E, Agostini M, Mitchell C, Schoenmakers N, Papp L, Rajanayagam O, Padidela R, Ceron-Gutierrez L, Doffinger R, Prevosto C, Luan J, Montano S, Lu J, Castanet M, Clemons N, Groeneveld M, Castets P, Karbaschi M, Aitken S, Dixon A, Williams J, Cam. The Journal of clinical investigation. 2010;120:4220-35.

PubMed: 21084748 · PMC: PMC2993594

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