ABCB1 / MDR1 / P Glycoprotein Antibody
Catalog Number: LS-C394331
2 sizes / from $300.00
Antibody: Rabbit Polyclonal
Applications: Enzyme-Linked Immunosorbent Assay
Reactivity: Protozoa / Protozoan Parasite
Format: Liquid
Anti-MDR1 antibody IHC of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
IHC-plus™ ABCB1 / MDR1 / P Glycoprotein Antibody
Primary AntibodyLSBio Guarantee
| Antibody: | Rabbit Polyclonal |
| Applications: | Enzyme-Linked Immunosorbent Assay, Immunohistochemistry (general), Immunohistochemistry, Paraffin, Western Blot |
| Format: | Liquid |
$526.00each
Catalog Number: LS-B1448-50
Catalog Number: LS-B1448
For bulk orders or custom formulations:
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- Description
- P Glycoprotein antibody LS-B1448 is an unconjugated rabbit polyclonal antibody to human P Glycoprotein (ABCB1 / MDR1). Validated for ELISA, IHC and WB. Tested on 20 paraffin-embedded human tissues. Cited in 3 publications.
- Application
- ELISA, IHC, IHC-P, WB
- Predicted Reactivity
- Dog, Human, Mouse, Non-Human Primate, Rat
- Intended Use
- Research Use Only
- Guarantees
- This product carries the LSBio 100% Guarantee. ✓
- Category
- Antibodies > Primary Antibodies > Polyclonal Antibodies
- Alternative Names
- ABC20 | ABCB1 | Abcb1b | CLCS | Colchicin sensitivity | CD243 | IBD13 | gp170 | MDR1 | Multidrug resistance protein 1 | P glycoprotein | P-glycoprotein 1 | P-GP | CD243 antigen | PGY1
- Recommended Dilution: ELISA
- 1:10000 - 1:50000
- Recommended Dilution: IHC-P
- 5 µg/ml
- Recommended Dilution: WB
- 1:200 - 1:2000
- UniProt Number
- P08183
- NCBI GenBank
- NM_000927 | NP_000918.2
- SwissProt
- P08183
Target
- Target
- ABCB1 / MDR1 / P Glycoprotein
- Antigen Species
- Human
- Specificity
- A BLAST analysis was used to suggest cross reactivity with ABCB1 protein from human, monkey, dog, mouse, and rat based on 100% homology with the immunizing sequence. Reactivity against homologues from other sources is not known.
- Epitope
- A BLAST analysis was used to suggest cross reactivity with ABCB1 protein from human, monkey, dog, mouse, and rat based on 100% homology with the immunizing sequence. Reactivity against homologues from other sources is not known.
- Gene Name
- ABCB1
Antibody
- Host Species
- Rabbit
- Clonality
- Polyclonal
- Origin Species
- Human
Immunogen
- Immunogen
- This affinity purified antibody was prepared from whole rabbit serum produced by repeated immunizations with a synthetic peptide corresponding to an internal region near amino acids 255-280 of human ABCB1 protein.
- Immunogen Type
- Synthetic Peptide (Linear)
Format
- Conjugate/Label
- Unconjugated
- Format
- Liquid
- Formulation
- 0.02 M Potassium Phosphate, pH 7.2, 0.15 M NaCl, 0.01% Sodium Azide
- Concentration
- 1 mg/mL
- Animal Free
- No
- Carrier-Free
- Yes
- Preservative
- Yes
- Purification Method
- Affinity Purified
Storage & Handling
- Storage Conditions
- Aliquot and store at -20°C or below for extended storage. Avoid freeze / thaw cycles. This product is stable for several weeks at 4°C as an undiluted liquid. Dilute only prior to immediate use. Centrifuge product if not completely clear after standing at room temperature.
- Recommended Storage Buffer
- 0.02 M Potassium Phosphate, 0.15 M NaCl
miR-200c inhibits melanoma progression and drug resistance through down-regulation of BMI-1. Liu S, Tetzlaff MT, Cui R, Xu X. The American journal of pathology. 2012 Nov;181:1823-35.
PubMed: 22982443 · PMC: PMC3483804
miR-200c/Bmi1 axis and epithelial-mesenchymal transition contribute to acquired resistance to BRAF inhibitor treatment. Liu S, Tetzlaff MT, Wang T, Yang R, Xie L, Zhang G, Krepler C, Xiao M, Beqiri M, Xu W, Karakousis G, Schuchter L, Amaravadi RK, Xu W, Wei Z, Herlyn M, Yao Y, Zhang L, Wang Y, Zhang L, Xu X. Pigment cell & melanoma research. 2015;28:431-41.
PubMed: 25903073 · PMC: PMC4597606
Chemotherapy-Induced IL8 Upregulates MDR1/ABCB1 in Tumor Blood Vessels and Results in Unfavorable Outcome. Hiroshi Kikuchi, Nako Maishi, Dorcas A Annan, Mohammad Towfik Alam, Randa Ibrahim Hassan Dawood, Masumi Sato, Masahiro Morimoto, Ryo Takeda, Keita Ishizuka, Ryuji Matsumoto, Tomoshige Akino, Kunihiko Tsuchiya, Takashige Abe, Takahiro Osawa, Naoto Miyajima, Satoru Maruyama, Toru Harabayashi, Manabu Azuma, Katsushige Yamashiro, Kaname Ameda, Akira Kashiwagi, Yoshihiro Matsuno, Yasuhiro Hida, Nobuo Shinohara, Kyoko Hida. Cancer research. 2020 July;80:2996-3008.
PubMed: 32536602
