FBX09 / FBXO9 Antibody (FITC)

Primary AntibodyLSBio Guarantee

Antibody:	Rabbit Polyclonal
Applications:	Enzyme-Linked Immunosorbent Assay
Reactivity:	Human
Format:	Liquid

$300.00each

Catalog Number: LS-C501938-50

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Description: FBXO9 antibody LS-C501938 is an FITC-conjugated rabbit polyclonal antibody to human FBXO9 (FBX09). Validated for ELISA.
Application: ELISA
Reactivity: Hu
Intended Use: Research Use Only
Guarantees: This antibody carries the LSBio 100% Guarantee. ✓
Category: Antibodies > Primary Antibodies > Polyclonal Antibodies
Alternative Names: F-box protein Fbx9 | FBX09 | FBX9 | FBXO9 | NY-REN-57 | VCIA1 | DJ341E18.2 | F-box only protein 9 | F-box protein 9
UniProt Number: Q9UK97
NCBI GenBank: NM_012347 | NP_036479.1
SwissProt: Q9UK97

Target: Human FBX09 / FBXO9
Antigen Species: Human
Epitope: Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of TTI1 and TELO2 in a CK2-dependent manner, thereby directly regulating mTOR signaling. SCF(FBXO9) recognizes and binds mTORC1-bound TTI1 and TELO2 when they are phosphorylated by CK2 following growth factor deprivation, leading to their degradation. In contrast, the SCF(FBXO9) does not mediate ubiquitination of TTI1 and TELO2 when they are part of the mTORC2 complex. As a consequence, mTORC1 is inactivated to restrain cell growth and protein translation, while mTORC2 is activated due to the relief of feedback inhibition by mTORC1.
Gene Name: FBXO9

Storage Conditions: Short term: -20°C; Long term: -80°C; Avoid freeze-thaw cycles.
Recommended Storage Buffer: PBS

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