CLEC7A / Dectin 1 Antibody (clone 2A11)
Primary AntibodyLSBio Guarantee
| Antibody: | Rat Monoclonal |
| Applications: | Flow Cytometry, Immunohistochemistry, Frozen, Immunoprecipitation |
| Reactivity: | Mouse |
| Format: | Liquid |
$455.00each
Catalog Number: LS-C188265-0.25
Catalog Number: LS-C188265
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- Description
- Dectin 1 antibody LS-C188265 is an unconjugated rat monoclonal antibody to mouse Dectin 1 (CLEC7A). Validated for Flow, IHC and IP.
- Application
- FC, IHC-F, IP
- Reactivity
- Ms
- Intended Use
- Research Use Only
- Guarantees
- This antibody carries the LSBio 100% Guarantee. ✓
- Category
- Antibodies > Primary Antibodies > Monoclonal Antibodies
- Alternative Names
- BGR | CANDF4 | CLECSF12 | Dectin-1 | DC-associated C-type lectin 1 | DECTIN1 | CLEC7A | HDectin-1 | Beta-glucan receptor | Lectin-like receptor 1 | CD369
- Recommended Dilution: FC
- 1:10 - 1:50
- UniProt Number
- Q9BXN2
- NCBI GenBank
- NM_022570 | NP_072092.2
- SwissProt
- Q9BXN2
Target
- Target
- Mouse CLEC7A / Dectin 1
- Antigen Species
- Mouse
- Epitope
- Recognizes murine beta-glucan receptor, also known as Dectin-1. Dectin-1 is predominantly expressed by cells of the monocyte/macrophage and neutrophil lineages, but also at lower levels by dendritic cells and a subpopulation of T cells. As a major leucocyte receptor for beta-glucan this molecule may have a key role in the immunomodulatory effects of beta-glucans and in the host response to fungal pathogens. Recent work has shown that Dectin-1 may stimulate reactive oxygen production in macrophages via the protein tyrosine kinase known as Syk. Inhibits the binding of zymosan to macrophages via the beta-glucan receptor. The low endotoxin version is recommended for functional studies.
- Gene Name
- CLEC7A
Antibody
- Host Species
- Rat
- Clonality
- Monoclonal
- Clone
- 2A11
- Isotype
- IgG2b
Immunogen
- Immunogen
- Dectin-1 transfected NIH3T3 cells and recombinant soluble Dectin-1.
- Immunogen Type
- Cell-Based Immunization
Format
- Conjugate/Label
- Unconjugated
- Format
- Liquid
- Formulation
- PBS, 0.09% Sodium Azide
- Concentration
- 1 mg/mL
- Preservative
- Yes
- Purification Method
- Protein G Affinity
Storage & Handling
- Storage Conditions
- Store at 4°C. Do not freeze. Store undiluted. Microcentrifugation recommended if solution contains precipitate.
- Recommended Storage Buffer
- PBS