Flow cytometry of human peripheral blood monocytes wtih Mouse anti-Human Dectin:FITC This image was taken for the unconjugated form of this product. Other forms have not been tested.
CLEC7A / Dectin 1 Antibody (clone GE2, FITC)
Primary AntibodyLSBio Guarantee
| Antibody: | Mouse Monoclonal |
| Applications: | Flow Cytometry |
| Reactivity: | Human |
| Format: | Liquid |
$335.00each
Catalog Number: LS-C188490-0.1
Catalog Number: LS-C188490
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- Description
- Dectin 1 antibody LS-C188490 is an FITC-conjugated mouse monoclonal antibody to human Dectin 1 (CLEC7A). Validated for Flow.
- Application
- FC
- Reactivity
- Hu
- Intended Use
- Research Use Only
- Guarantees
- This antibody carries the LSBio 100% Guarantee. ✓
- Category
- Antibodies > Primary Antibodies > Monoclonal Antibodies
- Alternative Names
- BGR | CANDF4 | CLECSF12 | Dectin-1 | DC-associated C-type lectin 1 | DECTIN1 | CLEC7A | HDectin-1 | Beta-glucan receptor | Lectin-like receptor 1 | CD369
- Recommended Dilution: FC
- 0.0423611111111111 - 1:10
- UniProt Number
- Q9BXN2
- NCBI GenBank
- NM_022570 | NP_072092.2
- SwissProt
- Q9BXN2
Target
- Target
- Human CLEC7A / Dectin 1
- Antigen Species
- Human
- Epitope
- Recognizes human Dectin-1, also known as beta-glucan receptor (GR), a C-type lectin domain family member. It is a major pathogen pattern-recognition receptor that binds beta-glucans, glucose polymers that form cell-wall components or exopolymers of yeasts, fungi and some bacteria. Beta-glucans have also been used experimentally and therapeutically as immunomodulators that enhance resistance to bacterial, yeast, viral and protozoan infections, as well as tumor formation. Dectin-1 also acts as a co-stimulatory molecule on T-cells to induce their proliferation and is necessary for the TLR2-mediated inflammatory response. It is highly expressed on peripheral blood leukocytes and dendritic cells. Human Dectin-1 has two major (GR-A and GR-B) and several minor isoforms. GR-A and GR-B differs by the presence and absence, respectively, of a stalk region. The antibody (clone GE2) recognizes both of these isoforms. Clone GE2 could be used to inhibit receptor function.
- Gene Name
- CLEC7A
Antibody
- Host Species
- Mouse
- Clonality
- Monoclonal
- Clone
- GE2
- Isotype
- IgG1
Immunogen
- Immunogen
- NIH3T3 cells expressing full length Beta-glucan receptor.
- Immunogen Type
- Cell-Based Immunization
Format
- Conjugate/Label
- Fluorescein Isothiocyanate
- Format
- Liquid
- Formulation
- PBS, 0.09% Sodium Azide, 1% BSA
- Concentration
- 0.1 mg/mL
- Preservative
- Yes
- Purification Method
- Protein G Affinity
Storage & Handling
- Storage Conditions
- Store at 4°C or at -20°C. Store undiluted. Avoid freeze-thaw cycles. Protect from light. Microcentrifugation recommended if solution contains precipitate.
- Recommended Storage Buffer
- PBS