LSBio
Monoclonal Mouse anti-Human CLEC7A / Dectin 1 Antibody (clone GE2, RPE)

Flow cytometry of human peripheral blood monocytes wtih Mouse anti-Human Dectin:RPE This image was taken for the unconjugated form of this product. Other forms have not been tested.

Monoclonal Mouse anti-Human CLEC7A / Dectin 1 Antibody (clone GE2, RPE)

Primary AntibodyLSBio Guarantee
Antibody:Mouse Monoclonal
Applications:Flow Cytometry
Reactivity:Human
Format:Lyophilized
See all Human CLEC7A / Dectin 1 antibodies →
$413.00each
Catalog Number: LS-C188492-100

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Overview

Description
Dectin 1 antibody LS-C188492 is an RPE-conjugated mouse monoclonal antibody to human Dectin 1 (CLEC7A). Validated for Flow.
Application
FC
Reactivity
Hu
Intended Use
Research Use Only
Guarantees
This antibody carries the LSBio 100% Guarantee. ✓
Category
Antibodies > Primary Antibodies > Monoclonal Antibodies
Alternative Names
BGR | CANDF4 | CLECSF12 | Dectin-1 | DC-associated C-type lectin 1 | DECTIN1 | CLEC7A | HDectin-1 | Beta-glucan receptor | Lectin-like receptor 1 | CD369
Recommended Dilution: FC
0.0423611111111111
UniProt Number
Q9BXN2
NCBI GenBank
NM_022570 | NP_072092.2
SwissProt
Q9BXN2

Target

Target
Human CLEC7A / Dectin 1
Antigen Species
Human
Epitope
Recognizes human Dectin-1, also known as beta-glucan receptor (GR), a C-type lectin domain family member. It is a major pathogen pattern-recognition receptor that binds beta-glucans, glucose polymers that form cell-wall components or exopolymers of yeasts, fungi and some bacteria. Beta-glucans have also been used experimentally and therapeutically as immunomodulators that enhance resistance to bacterial, yeast, viral and protozoan infections, as well as tumor formation. Dectin-1 also acts as a co-stimulatory molecule on T-cells to induce their proliferation and is necessary for the TLR2-mediated inflammatory response. It is highly expressed on peripheral blood leukocytes and dendritic cells. Human Dectin-1 has two major (GR-A and GR-B) and several minor isoforms. GR-A and GR-B differs by the presence and absence, respectively, of a stalk region. The antibody (clone GE2) recognizes both of these isoforms. Clone GE2 could be used to inhibit receptor function.
Gene Name
CLEC7A

Antibody

Host Species
Mouse
Clonality
Monoclonal
Clone
GE2
Isotype
IgG1

Immunogen

Immunogen
NIH3T3 cells expressing full length Beta-glucan receptor.
Immunogen Type
Cell-Based Immunization

Format

Conjugate/Label
Phycoerythrin
Format
Lyophilized
Formulation
PBS, 0.09% Sodium Azide, 5% Sucrose, 1% BSA
Preservative
Yes
Purification Method
Protein G Affinity

Storage & Handling

Storage Conditions
Store at 4°C. Do not freeze. Store undiluted. Protect from light. Microcentrifugation recommended if solution contains precipitate.
Recommended Storage Buffer
PBS

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To request an SDS/MSDS form for this product, please contact our Technical Support department at: technical@vectorlabs.com.