Formalin-fixed, paraffin-embedded human Colon Carcinoma stained with E-Cadherin Mouse Recombinant Monoclonal Antibody (rCDH1/1525).
CDH1 / E Cadherin Antibody (clone rCDH1/1525, Azide-free, Carrier-free)
Primary AntibodyLSBio Guarantee
| Antibody: | Mouse Recombinant Monoclonal |
| Applications: | Immunofluorescence, Immunohistochemistry, Paraffin, Western Blot |
| Reactivity: | Human |
| Format: | Liquid |
$586.00each
Catalog Number: LS-C751498-100
Catalog Number: LS-C751498
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- Description
- E Cadherin antibody LS-C751498 is an unconjugated mouse recombinant monoclonal antibody to human E Cadherin (CDH1). Validated for IF, IHC and WB.
- Application
- IF, IHC-P, WB
- Reactivity
- Hu
- Nonreactive Species
- Mouse, Rat
- Intended Use
- Research Use Only
- Guarantees
- This antibody carries the LSBio 100% Guarantee. ✓
- Category
- Antibodies > Primary Antibodies > Recombinant Antibodies
- Alternative Names
- CDH1 | CD324 | CDHE | Cell-CAM 120/80 | E Cadherin | E-Cadherin | ECAD | Epithelial cadherin | Arc-1 | UVO | Cadherin-1 | CAM 120/80 | CD324 antigen | LCAM | Uvomorulin
- Recommended Dilution: IF/ICC
- 1 - 2 µg/ml
- Recommended Dilution: IHC-P
- 1 - 2 µg/ml
- Recommended Dilution: WB
- 0.5 - 1 µg/ml
- UniProt Number
- P12830
- NCBI GenBank
- NM_004360 | NP_004351.1
- SwissProt
- P12830
Target
- Target
- Human CDH1 / E Cadherin
- Antigen Species
- Human
- Epitope
- Recognizes a protein of 120-80 kDa , identified as E-cadherin. Cadherins comprise a family of Ca2+-dependent adhesion molecules that function to mediate cell-cell binding critical to the maintenance of tissue structure and morphogenesis. The classical cadherins, E-, N- and P-cadherin, consist of large extracellular domains characterized by a series of five homologous NH2 terminal repeats. The relatively short intracellular domains interact with a variety of cytoplasmic proteins, such as beta-catenin, to regulate cadherin function. E-cadherin plays an important role in epithelial cell adhesion. A decreased expression of E-cadherin is associated with metastatic potential and poor prognosis in breast cancer, prostate and esophageal cancer. In combination with p120 Catenin, it is useful for the differentiation between ductal (E-cadherin +) and lobular (E-cadherin -) breast carcinomas. It may also help in diagnosis of mesothelioma.
- Gene Name
- CDH1
Antibody
- Host Species
- Mouse
- Clonality
- Recombinant Monoclonal
- Clone
- rCDH1/1525
- Isotype
- IgG1
- Origin Species
- Human
Immunogen
- Immunogen
- Recombinant full-length human E-Cadherin protein. Antigen Molecular Weight: 120-80 kDa (Mature) - 135 kDa (Precursor)
- Immunogen Type
- Recombinant Immunogen
Format
- Conjugate/Label
- Unconjugated
- Format
- Liquid
- Formulation
- 10 mM PBS
- Concentration
- 1 mg/mL
- Preservative
- No
- Purification Method
- Protein A/G Affinity
Storage & Handling
- Storage Conditions
- Store at -20°C to -80°C for up to 2 years.
- Recommended Storage Buffer
- 10 mM PBS