Human peripheral blood monocytes stained with Mouse anti-Human CD300a:RPE This image was taken for the unconjugated form of this product. Other forms have not been tested.

CD300A Antibody (clone P192, RPE)

Primary AntibodyLSBio Guarantee

Antibody:	Mouse Monoclonal
Applications:	Flow Cytometry
Reactivity:	Human
Format:	Lyophilized

$413.00each

Catalog Number: LS-C187548-100

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Overview

Description: CD300A antibody LS-C187548 is an RPE-conjugated mouse monoclonal antibody to human CD300A. Validated for Flow.
Application: FC
Reactivity: Hu
Intended Use: Research Use Only
Guarantees: This antibody carries the LSBio 100% Guarantee. ✓
Category: Antibodies > Primary Antibodies > Monoclonal Antibodies
Alternative Names: CD300A | CD300a antigen | CD300a molecule | CMRF35-like molecule 8 | CMRF35-H | CMRF35-H9 | CLM-8 | CMRF35H9 | IGSF12 | Inhibitory receptor protein 60 | IRC2 | IRC1 | NK inhibitory receptor | CMRF-35-H9 | CMRF-35H | CMRF35H | IRC1a | IRp60 | Leukocyte membrane antigen
UniProt Number: Q9UGN4
NCBI GenBank: NM_007261
SwissProt: Q9UGN4

Target

Target: Human CD300A
Antigen Species: Human
Epitope: Recognizes human CD300a, otherwise known as IRp60 (inhibitory receptor protein 60), a 60kD transmembrane glycoprotein expressed by natural killer cells (NK), T and B cell subsets, monocytes, neutrophils, macrophages, granulocytes, dendritic cells (DC) and mast cells. Studies have shown that the cross-linking of CD300a on NK results in a down-regulation of their cytolytic activity, whilst cross-linking of CD300a on mast cells, inhibits IgE-induced degranulation and SCF-mediated survival. Furthermore, cross-linking of CD300a on the surface of eosinophils has been shown to significantly inhibit their survival, chemotaxis and activation in response to certain inflammatory cytokines, whilst eosinophil-derived MBP (major basic protein) and EDN (neurotoxin), can down-regulate CD300a expression on mast cells in vitro.
Gene Name: CD300A

Antibody

Host Species: Mouse
Clonality: Monoclonal
Clone: P192
Isotype: IgG2a

Immunogen

Immunogen: Polyclonal population of NK cells.
Immunogen Type: Cell-Based Immunization

Format

Conjugate/Label: Phycoerythrin
Format: Lyophilized
Formulation: PBS, 0.09% Sodium Azide, 5% Sucrose, 1% BSA
Preservative: Yes
Purification Method: Protein G Affinity

Storage & Handling

Storage Conditions: Store at 4°C. Do not freeze. Store undiluted. Protect from light. Microcentrifugation recommended if solution contains precipitate.
Recommended Storage Buffer: PBS