Human peripheral blood monocytes stained with Mouse anti-Human CD300a followed by Rabbit F(ab')2 anti-Mouse IgG:FITC

CD300A Antibody (clone P192)

Primary AntibodyLSBio Guarantee

Antibody:	Mouse Monoclonal
Applications:	Flow Cytometry, Immunohistochemistry (general)
Reactivity:	Human
Format:	Liquid

$392.00each

Catalog Number: LS-C187546-0.2

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Description: CD300A antibody LS-C187546 is an unconjugated mouse monoclonal antibody to human CD300A. Validated for Flow.
Application: FC, IHC
Reactivity: Hu
Intended Use: Research Use Only
Guarantees: This antibody carries the LSBio 100% Guarantee. ✓
Category: Antibodies > Primary Antibodies > Monoclonal Antibodies
Alternative Names: CD300A | CD300a antigen | CD300a molecule | CMRF35-like molecule 8 | CMRF35-H | CMRF35-H9 | CLM-8 | CMRF35H9 | IGSF12 | Inhibitory receptor protein 60 | IRC2 | IRC1 | NK inhibitory receptor | CMRF-35-H9 | CMRF-35H | CMRF35H | IRC1a | IRp60 | Leukocyte membrane antigen
UniProt Number: Q9UGN4
NCBI GenBank: NM_007261
SwissProt: Q9UGN4

Target: Human CD300A
Antigen Species: Human
Epitope: Recognizes human CD300a, otherwise known as IRp60 (inhibitory receptor protein 60), a 60kD transmembrane glycoprotein expressed by natural killer cells (NK), T and B cell subsets, monocytes, neutrophils, macrophages, granulocytes, dendritic cells (DC) and mast cells. Studies have shown that the cross-linking of CD300a on NK results in a down-regulation of their cytolytic activity, whilst cross-linking of CD300a on mast cells, inhibits IgE-induced degranulation and SCF-mediated survival. Furthermore, cross-linking of CD300a on the surface of eosinophils has been shown to significantly inhibit their survival, chemotaxis and activation in response to certain inflammatory cytokines, whilst eosinophil-derived MBP (major basic protein) and EDN (neurotoxin), can down-regulate CD300a expression on mast cells in vitro.
Gene Name: CD300A

Storage Conditions: Store at 4°C to 20°C. Store undiluted. Avoid freeze-thaw cycles. Microcentrifugation recommended if solution contains precipitate.
Recommended Storage Buffer: PBS