LSBio
Mouse IL-1B / IL-1 Beta Protein (Recombinant)

Biological Activity IL-1beta, Mouse stimulates cell proliferation of D10S cells. The ED 50 for this effect is less than 2pg/mL.

Mouse IL-1B / IL-1 Beta Protein (Recombinant)

ProteinLSBio Guarantee
Expression SystemEscherichia coli (Prokaryotic)
Format:Lyophilized
See all IL1B antibodies →
$311.00each
Catalog Number: LS-G27070-10

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Overview

Description
Interleukin-1 Beta (IL-1Beta) is a proinflammatory cytokine produced in a variety of cells including monocytes, tissue macrophages, keratinocytes and other epithelial cells. Both IL-1 alpha and IL-1 beta binds to the same receptor and has similar if not identical biological properties. These cytokines have a broad range of activities including, stimulation of thymocyte proliferation, by inducing IL-2 release, B-cell maturation and proliferation, mitogenic FGF-like activity and the ability to stimulate the release of prostaglandin and collagenase from synovial cells. However, whereas IL-1 beta is a secreted cytokine, IL-1 alpha is predominantly a cell-associated cytokine. Recombinant mouse Interleukin-1 Beta(rmIL-1Beta) produced in E. coli is a single non-glycosylated polypeptide chain containing 153 amino acids. A fully biologically active molecule, rmIL-1Beta is obtained by chromatographic techniques, with an apparent molecular weight of 17.5kDa analyzed by reducing SDS-PAGE.
Category
Proteins & Peptides > Proteins > Recombinant Proteins
Alternative Names
IL-1B | IL1B | IL-1 beta | IL1-BETA | Preinterleukin 1 beta | Pro-interleukin-1-beta | Catabolin | IL-1 | IL1F2 | Interleukin 1 | beta | Interleukin-1 beta
Origin Species
Mouse
NCBI GenBank
NM_000576|NP_000567.1
SwissProt
P01584

Protein

Expression System
Escherichia coli (Prokaryotic)
Molecular Weight
17.5 kDa (SDS-PAGE)
Protein Type
Recombinant
Amino Acid Sequence
1MVPIRQLHYR LRDEQQKSLV LSDPYELKAL HLNGQNINQQ VIFSMSFVQG EPSNDKIPVA
61LGLKGKNLYL SCVMKDGTPT LQLESVDPKQ YPKKKMEKRF VFNKIEVKSK VEFESAEFPN
121WYISTSQAEH KPVFLGNNSG QDIIDFTMES VSS

153 aa

Format

Purity
>95%
Conjugate/Label
Unconjugated
Endotoxin Level
< 0.2 EU/µg
Format
Lyophilized
Formulation
Lyophilized from PBS
Purity Measurement Method
SDS-PAGE (Coomassie Stain)

Storage & Handling

Storage Conditions
Stable at -80°c for up to 6 months. Upon reconstitution, store at 4°c for up to 2 weeks or at -20°c for up to 3 months.

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To request an SDS/MSDS form for this product, please contact our Technical Support department at: technical@vectorlabs.com.