Overview

Description

Herpes Virus Entry Mediator (HVEM) is a transmembrane protein that is the receptor for TNFSF14 (also known as LIGHT) and is therefore referred to asTNFRSF14. HVEM is expressed broadly on immune cells such as T cells, natural killer (NK) cells and monocytes. The interaction of 3 molecules of LIGHT with three molecules of HVEM forms a hexameric complex that leads to the recruitment and retention of effector cells and activates NK cells to produce large amounts of IFN-gamma and GM-CSF. In addition to the canonical binding partner LIGHT, HVEM can also bind to the inhibitory signaling protein, B- and T- lymphocyte attenuator (BTLA),which suppresses immune responses. Therefore, the HVEM network plays an important role in regulating immunity and the behavior of lymphocytes.Recombinant human HVEM-Fc (rhHVEM-Fc) produced in Sf9 insect cells is a single glycosylated polypeptide chain containing 376 amino acids. A fully biologically active molecule, rhHVEM-Fc has a molecular mass of around 45 kDa analyzed by reducing SDS-PAGE and is obtained by chromatographic techniques.

Category

Proteins & Peptides > Proteins > Recombinant Proteins

Alternative Names

CD270 | CD270 antigen | CD40-like protein | Herpesvirus entry mediator | Herpesvirus entry mediator A | HVEM | LIGHTR | Herpes virus entry mediator A | TR2 | ATAR | HVEA | TNFRSF14

Origin Species

Human

NCBI GenBank

NM_003820|NP_003811.2

SwissProt

Q92956