The ED(50) was determined by the dose-dependent proliferation of human umbilical vein endothelial cells and was found to be <0.2ng/mL.

Human TNFRSF12A / TWEAK Receptor Protein (Recombinant)

Expression System	Escherichia coli (Prokaryotic)
Format:	Lyophilized

$331.00each

Catalog Number: LS-G131449-25

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Description: Tumor necrosis factor receptor superfamily member 12A (TNFRSF12A) is the receptor for TNFSD12/TWEAK and is the smallest member of the TNF receptor superfamily. It is composed of a signal peptide, an extracellular domain, a membrane-anchoring domain, and a cytoplasmic "death" domain, which can activate a cell's apoptotic mechanisms. It also promotes endothelial cell proliferation and angiogenesis, and modulates cellular adhesion to matrix proteins. TNFRSF12A expression can be found in the spleen, thymus, small intestine, and colon, and can be activated by membrane-anchored or soluble versions of TWEAK.
Category: Proteins & Peptides > Proteins > Recombinant Proteins
Alternative Names: CD266 antigen | CD266 | FGF-inducible 14 | TNFRSF12A | FN14 | Tweak-receptor | TWEAKR
Origin Species: Human
NCBI GenBank: NM_016639
SwissProt: Q9NP84

Storage Conditions: The lyophilized protein is stable for up to 1 year at -70°C. Upon reconstitution, this cytokine can be stored in working aliquots at 2°C to 8°C for 1 month, or at -20°C for 6 months, with a carrier protein without detectable loss of activity. Avoid freeze/thaw cycles.