LSBio
Human SFTPD / Surfactant Protein D (Recombinant)

Human SFTPD / Surfactant Protein D (Recombinant)

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Expression SystemHuman Embryonic Kidney 293
Format:Lyophilized
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$332.00each
Catalog Number: LS-G27026-50

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Overview

Description
Surfactant protein D is a member of the collectin family of innate immune modulators. It is constitutively secreted by alveolar lining cells and epithelium associated with tubular structures, that contains a N-terminal collagen-like domain and a C-terminal lectin domain that are characteristic of members of the collectin family of proteins, and also shows calcium-dependent binding to specific saccharides. Besides it is involved in the development of acute and chronic inflammation of the lung. Several human lung diseases are characterized by decreased levels of bronchoalveolar SP-D. Recombinant Human SP-D produced in HEK 293 cells is a polypeptide chain containing 355 amino acids. A fully biologically active molecule, rhSP-D has a molecular mass of 40-45 kDa analyzed by reducing SDS-PAGE and is obtained by chromatographic techniques.
Category
Proteins & Peptides > Proteins > Recombinant Proteins
Alternative Names
COLEC7 | Collectin 7 | Collectin-7 | Lung surfactant protein D | PSP-D | PSPD | SP-D | SFTPD | SFTP4 | Surfactant protein D
Origin Species
Human
NCBI GenBank
NM_003019|NP_003010.4
SwissProt
P35247

Protein

Expression System
Human Embryonic Kidney 293
Molecular Weight
40-45 kDa (SDS-PAGE)
Protein Type
Recombinant
Amino Acid Sequence
1AEMKTYSHRT MPSACTLVMC SSVESGLPGR DGRDGREGPR GEKGDPGLPG AAGQAGMPGQ
61AGPVGPKGDN GSVGEPGPKG DTGPSGPPGP PGVPGPAGRE GPLGKQGNIG PQGKPGPKGE
121AGPKGEVGAP GMQGSAGARG LAGPKGERGV PGERGVPGNT GAAGSAGAMG PQGSPGARGP
181PGLKGDKGIP GDKGAKGESG LPDVASLRQQ VEALQGQVQH LQAAFSQYKK VELFPNGQSV
241GEKIFKTAGF VKPFTEAQLL CTQAGGQLAS PRSAAENAAL QQLVVAKNEA AFLSMTDSKT
301EGKFTYPTGE SLVYSNWAPG EPNDDGGSED CVEIFTNGKW NDRACGEKRL VVCEF

355 aa

Format

Purity
>98%
Conjugate/Label
Unconjugated
Endotoxin Level
< 0.2 EU/µg
Format
Lyophilized
Formulation
Lyophilized from Sterile Solution PBS
Purity Measurement Method
SDS-PAGE (Coomassie Stain)

Storage & Handling

Storage Conditions
Stable at -80°c for up to 6 months. Upon reconstitution, store at 4°c for up to 1 week or at -20°c for up to 3 months. For long term storage it is recommended that a carrier protein be added. Avoid repeated freeze-thaw cycles.

Request SDS/MSDS

To request an SDS/MSDS form for this product, please contact our Technical Support department at: technical@vectorlabs.com.