LSBio
Human IL6R / IL6 Receptor Protein (Recombinant)

Human IL6R / IL6 Receptor Protein (Recombinant)

ProteinLSBio Guarantee
Expression SystemChinese Hamster Ovary
Format:Lyophilized
See all IL6R antibodies →
$311.00each
Catalog Number: LS-G27205-10

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Overview

Description
Interleukin-6 Receptor Alpha, also known as IL-6RA, IL-6R1 and CD126, belongs to the type I cytokine receptor family. It is mainly expressed on T cells, fibroblasts and macrophages. IL-6RA couples with gp130 to form the IL-6 receptor; IL-6RA binds specifically to IL-6 and depends on gp130 to transmit signals. IL-6RA dysfunction has been correlated with the pathogenesis of many diseases, such as multiple myeloma, autoimmune diseases and prostate cancer. Soluble IL-6RA, which consists of only the extracellular domain of IL-6RA, acts as an agonist of IL-6 activity.
Category
Proteins & Peptides > Proteins > Recombinant Proteins
Alternative Names
CD126 | gp80 | IL-6R subunit alpha | IL-6R-alpha | IL-6RA | IL6Q | IL-6 receptor subunit alpha | IL-6R 1 | IL-6R-1 | Interleukin 6 receptor | Membrane glycoprotein 80 | CD126 antigen | IL6R | IL6RA | IL6RQ
Origin Species
Human
NCBI GenBank
NM_000565|NP_000556.1
SwissProt
P08887

Protein

Expression System
Chinese Hamster Ovary
Molecular Weight
54-56 kDa (SDS-PAGE)
Protein Type
Recombinant
Amino Acid Sequence
1aa 20-365  of P08887| LAPRRCPAQE VARGVLTSLP GDSVTLTCPG VEPEDNATVH
61WVLRKPAAGS HPSRWAGMGR RLLLRSVQLH DSGNYSCYRA GRPAGTVHLL VDVPPEEPQL
121SCFRKSPLSN VVCEWGPRST PSLTTKAVLL VRKFQNSPAE DFQEPCQYSQ ESQKFSCQLA
181VPEGDSSFYI VSMCVASSVG SKFSKTQTFQ GCGILQPDPP ANITVTAVAR NPRWLSVTWQ
241DPHSWNSSFY RLRFELRYRA ERSKTFTTWM VKDLQHHCVI HDAWSGLRHV VQLRAQEEFG
301QGEWSEWSPE AMGTPWTESR SPPAENEVST PMQALTTNKD DDNILFRDSA NATSLPVQDS
361SSVPLP

366 aa

Format

Purity
>95%
Conjugate/Label
Unconjugated
Endotoxin Level
< 0.2 EU/µg
Format
Lyophilized
Formulation
Lyophilized from PBS
Purity Measurement Method
SDS-PAGE (Coomassie Stain)

Storage & Handling

Storage Conditions
Stable at -80°c for up to 6 months. Upon reconstitution, store at 4°c for up to 1 week or at -20°c for up to 2 months.

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To request an SDS/MSDS form for this product, please contact our Technical Support department at: technical@vectorlabs.com.