LSBio
Human IL6R / IL6 Receptor Protein (Recombinant His, N-Terminal)

Human IL6R / IL6 Receptor Protein (Recombinant His, N-Terminal)

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Expression SystemBaculovirus / Sf9 Insect Cells
Format:Lyophilized
See all IL6R antibodies →
$268.00each
Catalog Number: LS-G27255-10

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Overview

Description
Interleukin-6 Receptor (IL-6R) is a single trans-membrane protein that is the receptor for Interleukin-6 (IL-6). IL-6R forms a hexameric complex upon binding 2 molecules of IL-6 and two molecules of glycoprotein 130 (gp130) which activates intracellular JAK/STAT pathways. Although the normal form of IL-6R is the membrane-bound 80 kDa subunit, a soluble form of IL-6R (sIL-6R) can be generated physiologically by limited proteolysis or alternative splicing. sIL-6R binds to both IL-6 and gp130 generating intracellular signaling. In the immune system, sIL-6R is produced by both naive and memory CD4 T-cells and strongly augments IL-6 ligand's induction of Th-17 cells.Recombinant human Soluble IL-6 Receptor Alpha (rhsIL-6R alpha) with an N-terminal His tag produced in Sf9 insect cells is a single glycosylated polypeptide chain containing 350 amino acids. A fully biologically active molecule, rhsIL-6R alpha has a molecular mass of 50kDa analyzed by reducing SDS-PAGE and is obtained by chromatographic techniques.
Category
Proteins & Peptides > Proteins > Recombinant Proteins
Alternative Names
CD126 | gp80 | IL-6R subunit alpha | IL-6R-alpha | IL-6RA | IL6Q | IL-6 receptor subunit alpha | IL-6R 1 | IL-6R-1 | Interleukin 6 receptor | Membrane glycoprotein 80 | CD126 antigen | IL6R | IL6RA | IL6RQ
Origin Species
Human
NCBI GenBank
NM_000565|NP_000556.1
SwissProt
P08887

Protein

Expression System
Baculovirus / Sf9 Insect Cells
Fusion Tag
Hexahistidine Tag
Molecular Weight
50 kDa (SDS-PAGE)
Protein Type
Recombinant
Amino Acid Sequence
1HHHHHHDDDD KLAPRRCPAQ EVARGVLTSL PGDSVTLTCP GVEPEDNATV HWVLRKPAAG
61SHPSRWAGMG RRLLLRSVQL HDSGNYSCYR AGRPAGTVHL LVDVPPEEPQ LSCFRKSPLS
121NVVCEWGPRS TPSLTTKAVL LVRKFQNSPA EDFQEPCQYS QESQKFSCQL AVPEGDSSFY
181IVSMCVASSV GSKFSKTQTF QGCGILQPDP PANITVTAVA RNPRWLSVTW QDPHSWNSSF
241YRLRFELRYR AERSKTFTTW MVKDLQHHCV IHDAWSGLRH VVQLRAQEEF GQGEWSEWSP
301EAMGTPWTES RSPPAENEVS TPMQALTTNK DDDNILFRDS ANATSLPVQD

350 aa

Format

Purity
>95%
Conjugate/Label
Unconjugated
Endotoxin Level
< 0.2 EU/µg
Format
Lyophilized
Formulation
Lyophilized from PBS
Purity Measurement Method
SDS-PAGE (Coomassie Stain)

Storage & Handling

Storage Conditions
Stable at -80°c for up to 6 months. Upon reconstitution, store at 4°c for up to 2 weeks or at -20°c for up to 3 months.

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To request an SDS/MSDS form for this product, please contact our Technical Support department at: technical@vectorlabs.com.