Measured by its binding ability in a functional ELISA. Immobilized human ErbB2 at 2.5 µg/ml can bind Herceptin with a linear range of 3.2-80 ng/ml.

Human ERBB2 / HER2 Protein (Recombinant Human IgG Fc, C-terminus)

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Expression System	Human Embryonic Kidney 293
Format:	Lyophilized

$450.00each

Catalog Number: LS-G47281-100

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Overview

Description: ERBB2 / HER2 Protein LS-G47281 is a Recombinant Human ERBB2 / HER2 produced in HEK 293 Cells Met1-Thr652 with Human IgG Fc, C-terminus tag(s). It is biologically active and is low in endotoxin; Less than 1.0 EU/µg protein (determined by LAL method). For Research Use Only
Category: Proteins & Peptides > Proteins > Recombinant Proteins
Alternative Names: C-erb B2/neu protein | CD340 | HER2 | Herstatin | MLN 19 | HER-2 | Neu | NGL | Proto-oncogene c-ErbB-2 | Proto-oncogene Neu | CD340 antigen | ERBB2 | MLN19 | p185erbB2 | TKR1
Origin Species: Hu
NCBI GenBank: NM_004448
SwissProt: P04626

Protein

Expression System: HEK293
Fusion Tag: hFc
Molecular Weight: The recombinant human ErbB2/Fc chimera is a disulfide-linked homodimeric protein generated by proteolytic removal of the signal peptide. The monomer comprises 868 amino acids and has a calculated molecular mass of 96.1 kDa. As a result of glycosylation, the monomer migrates as an approximately 130-140 kDa protein in SDS-PAGE under reducing conditions.
Protein Type: Recombinant
Amino Acid Sequence

Format

Purity: >90%
Conjugate/Label: Unconj
Endotoxin Level: < 1.0 EU/µg
Format: Lyophilized
Formulation: Lyophilized from sterile PBS, pH 7.4, 5% trehalose, 5% mannitol and 0.01% Tween80
Purity Measurement Method: SDS-PAGE