Overview

Description

Tumor Necrosis Factor-Alpha (TNF-alpha) plays a major role in growth regulation, differentiation, inflammation, viral replication, tumorigenesis, and autoimmune diseases. Besides inducing hemorrhagic necrosis of tumors, TNF has been found to be involved in tumorigenesis, tumor metastasis, viral replication, septic shock, fever, inflammation, and autoimmune diseases including Crohn's disease, and rheumatoid arthritis as well as graft-versus-host disease. TNF alpha-1a is a potent lymphoid factor that exerts cytotoxic effects on a wide range of tumor cells and certain other target cells. Recombinant human Tumor Necrosis Factor-Alpha (rhTNF-alpha) produced in Pichia pastoris is a glycosylated polypeptide chain of 157 amino acids. A fully biologically active molecule, rhTNF-alpha has a molecular mass of 17.4 kDa analyzed by reducing SDS-PAGE and is obtained by refolding and chromatographic techniques.

Category

Proteins & Peptides > Proteins > Recombinant Proteins

Alternative Names

COL18A1 | Collagen | type XVIII | alpha 1 | Collagen alpha-1(XVIII) chain | Endostatin | KNO | KNO1 | KS | Multi-functional protein MFP | Antiangiogenic agent | Collagen alpha 1(xviii) | Knobloch syndrome | type 1

Origin Species

Human

NCBI GenBank

NM_030582|NP_085059.2

SwissProt

P39060