LSBio
TRPV4 Antibody (Internal)

Anti-TRPV4 antibody IHC of human pancreas, islet. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

TRPV4 Antibody (Internal)

Primary AntibodyLSBio Guarantee
Antibody:Rabbit Polyclonal
Applications:Immunohistochemistry (general)
Reactivity:Bovine, Dog, Hamster, Horse, Human, Mouse, Non-Human Primate, Pig, Rat
Format:Liquid
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$449.00each
Catalog Number: LS-A8583-50

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Overview

Description
TRPV4 antibody LS-A8583 is an unconjugated rabbit polyclonal antibody to TRPV4 (Internal) from human. It is reactive with human, mouse, rat and other species. Validated for IF, IHC and WB. Tested on 20 paraffin-embedded human tissues. Cited in 3 publications.
Application
IHC
Reactivity
Bov, Can, Ham, Hr, Hu, Ms, NHP, Por, Rt
Predicted Reactivity
Chicken, Rabbit
Intended Use
Research Use Only
Guarantees
This product carries the LSBio 100% Guarantee.
Category
Antibodies > Primary Antibodies > Polyclonal Antibodies
Alternative Names
CMT2C | HMSN2C | OTRPC4 | SSQTL1 | VR-OAC | VRL-2 | TRPV4 | Osm-9-like TRP channel 4 | SPSMA | TRP12 | VRL2 | VROAC | SMAL
Recommended Dilution: IHC-P
5 - 10 µg/ml
UniProt Number
Q9HBA0
SwissProt
Q9HBA0

Target

Target
TRPV4
Antigen Species
Human
Specificity
TRPV4 from human, mouse, rat and other mammals. BLAST analysis of the peptide immunogen showed no homology with other human proteins
Epitope
Human TRPV4. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
Gene Name
TRPV4

Antibody

Host Species
Rabbit
Clonality
Polyclonal

Immunogen

Immunogen
Synthetic 20 amino acid peptide from internal region of human TRPV4. Percent identity with other species by BLAST analysis: Human, Gorilla, Gibbon, Monkey, Marmoset, Mouse, Rat, Hamster, Panda, Bovine, Dog, Horse, Pig (100%); Elephant, Rabbit (95%); Turkey, Chicken, Platypus (90%); Xenopus (85%); Stickleback, Zebrafish (80%).
Immunogen Type
Synthetic Peptide (Linear)

Format

Conjugate/Label
Unconjugated
Format
Liquid
Formulation
PBS, 0.1% Sodium Azide
Animal Free
No
Carrier-Free
Yes
Preservative
Yes
Purification Method
Affinity Purified

Storage & Handling

Storage Conditions
Aliquot and store undiluted at -20°C or below for up to 1 year. Can be stored undiluted at 4°C for up to 1 month. Avoid freeze-thaw cycles.
Recommended Storage Buffer
PBS

Activation of endothelial TRPV4 channels mediates flow-induced dilation in human coronary arterioles: role of Ca2+ entry and mitochondrial ROS signaling. Bubolz AH, Mendoza SA, Zheng X, Zinkevich NS, Li R, Gutterman DD, Zhang DX. American journal of physiology. Heart and circulatory physiology. 2012 Feb;302:H634-42.

PubMed: 22140047 · PMC: PMC3353785


Pregnancy-induced remodelling and enhanced endothelium-derived hyperpolarization-type vasodilator activity in rat uterine radial artery: transient receptor potential vanilloid type 4 channels, caveolae and myoendothelial gap junctions. Senadheera S, Bertrand PP, Grayson TH, Leader L, Murphy TV, Sandow SL. Journal of anatomy. 2013 Dec;223:677-86.

PubMed: 24128141


The expression and function of TRPV4 channels in primate retinal ganglion cells and bipolar cells. Gao F, Yang Z, Jacoby RA, Wu SM, Pang JJ. Cell death & disease. 2019 May;10:364.

PubMed: 31064977 · PMC: PMC6504919


Localization of TRP Channels in Healthy Oral Mucosa from Human Donors. Yalda Moayedi, Stephanie Michlig, Mark Park, Alia Koch, and Ellen A. Lumpkin. eNeuro. 2022 Dec;9.

PubMed: 36635242

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