Human peripheral blood lymphocytes stained with Mouse anti-Human Siglec-7: Endotoxin Low This image was taken for the unmodified form of this product. Other forms have not been tested.
SIGLEC7 / CD328 Antibody (clone S7.7, Low Endotoxin)
Primary AntibodyLSBio Guarantee
| Antibody: | Mouse Monoclonal |
| Applications: | Enzyme-Linked Immunosorbent Assay, Flow Cytometry, Immunoprecipitation, Western Blot |
| Reactivity: | Human |
| Format: | Liquid |
$654.00each
Catalog Number: LS-C187561-0.5
Catalog Number: LS-C187561
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- Description
- CD328 antibody LS-C187561 is an unconjugated mouse monoclonal antibody to human CD328 (SIGLEC7). Validated for ELISA, Flow, IP and WB.
- Application
- ELISA, FC, IP, WB
- Reactivity
- Hu
- Intended Use
- Research Use Only
- Guarantees
- This antibody carries the LSBio 100% Guarantee. ✓
- Category
- Antibodies > Primary Antibodies > Monoclonal Antibodies
- Alternative Names
- AIRM-1 | AIRM1 | CD328 antigen | CDw328 | CD328 | D-siglec | QA79 | SIGLEC-7 | SIGLEC7 | QA79 membrane protein
- UniProt Number
- Q9Y286
- NCBI GenBank
- NM_014385 | NP_055200.1
- SwissProt
- Q9Y286
Target
- Target
- Human SIGLEC7 / CD328
- Antigen Species
- Human
- Epitope
- Recognizes human Sialic acid-binding Ig-like lectin 7, otherwise known as CD328, a putative adhesion molecule and member of the Ig superfamily, predominantly expressed by both resting and activated natural killer (NK) cells, and also at lower levels by monocytes, granulocytes, monocyte-derived macrophages and dendritic cells, and a small population of CD8+ memory T cells. Classified as a CD33-related Siglec, Siglec-7 preferentially binds to glycoconjugates containing alpha-2,3- or alpha-2,6-linked sialic acid, and acts as a novel inhibitory receptor for NK cells, mediating the inhibition of NK cell cytotoxicity, and implicated in the regulation of NK cell and T cell activation, and hematopoiesis. Clone S7.7 is a blocking antibody see for details, and has been shown to recognize Siglec-7 in Rhesus monkey see for details.
- Gene Name
- SIGLEC7
Antibody
- Host Species
- Mouse
- Clonality
- Monoclonal
- Clone
- S7.7
- Isotype
- IgG1
Immunogen
- Immunogen
- Siglec-7 3T3 transfected cells.
- Immunogen Type
- Cell-Based Immunization
Format
- Conjugate/Label
- Unconjugated
- Format
- Liquid
- Formulation
- PBS
- Preservative
- No
- Purification Method
- Protein G Affinity
Storage & Handling
- Storage Conditions
- Store at -20°C. Store undiluted. Avoid freeze-thaw cycles. Microcentrifugation recommended if solution contains precipitate.
- Recommended Storage Buffer
- PBS