LSBio
Polyclonal Rabbit anti-Human Tuberin / TSC2 Antibody (IF, WB)

Positive WB detected in:Mouse lung tissue;All lanes: TSC2 antibody at 2.8ug/ml;Secondary;Goat polyclonal to rabbit IgG at 1/50000 dilution;Predicted band size: 201,196,199,194,190,188,26 kDa;Observed band size: 201 kDa;

Polyclonal Rabbit anti-Human Tuberin / TSC2 Antibody (IF, WB)

Primary AntibodyLSBio Guarantee
Antibody:Rabbit Polyclonal
Applications:Enzyme-Linked Immunosorbent Assay, Immunofluorescence, Western Blot
Reactivity:Human, Mouse
Format:Liquid
See all Human Tuberin / TSC2 antibodies →
$300.00each
Catalog Number: LS-C500509-50

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Overview

Description
TSC2 antibody LS-C500509 is an unconjugated rabbit polyclonal antibody to TSC2 (Tuberin) from human. It is reactive with human and mouse. Validated for ELISA, IF and WB.
Application
ELISA, IF, WB
Reactivity
Hu, Ms
Intended Use
Research Use Only
Guarantees
This antibody carries the LSBio 100% Guarantee. ✓
Category
Antibodies > Primary Antibodies > Polyclonal Antibodies
Alternative Names
LAM | Tuberous sclerosis 2 protein | TSC4 | Tuberin | Tuberous sclerosis 2 | TSC2
UniProt Number
P49815
NCBI GenBank
NM_000548 | NP_000539.2
SwissProt
P49815

Target

Target
Human Tuberin / TSC2
Antigen Species
Human
Epitope
In complex with TSC1, this tumor suppressor inhibits the nutrient-mediated or growth factor-stimulated phosphorylation of S6K1 and EIF4EBP1 by negatively regulating mTORC1 signaling. Acts as a GTPase-activating protein (GAP) for the small GTPase RHEB, a direct activator of the protein kinase activity of mTORC1. May also play a role in microtubule-mediated protein transport. Also stimulates the intrinsic GTPase activity of the Ras-related proteins RAP1A and RAB5.
Gene Name
TSC2

Antibody

Host Species
Rabbit
Clonality
Polyclonal
Isotype
IgG

Immunogen

Immunogen
Recombinant human Tuberin protein (1396-1496AA)
Immunogen Type
Recombinant Immunogen

Format

Conjugate/Label
Unconjugated
Format
Liquid
Formulation
PBS, pH 7.4, 0.03% Proclin 300, 50% glycerol.
Preservative
Yes
Purification Method
Protein G Affinity

Storage & Handling

Storage Conditions
Short term: -20°C; Long term: -80°C; Avoid freeze-thaw cycles.
Recommended Storage Buffer
PBS

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