LSBio
Polyclonal Rabbit anti-Human AUTL1 / ATG4C Antibody (IHC, IF)

Immunohistochemistry of paraffin-embedded human testis tissue using ATG4C Antibody at dilution of 1:100

Polyclonal Rabbit anti-Human AUTL1 / ATG4C Antibody (IHC, IF)

Primary AntibodyLSBio Guarantee
Antibody:Rabbit Polyclonal
Applications:Enzyme-Linked Immunosorbent Assay, Immunofluorescence, Immunohistochemistry (general)
Reactivity:Human
Format:Liquid
See all Human AUTL1 / ATG4C antibodies →
$300.00each
Catalog Number: LS-C501376-50

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Overview

Description
ATG4C antibody LS-C501376 is an unconjugated rabbit polyclonal antibody to human ATG4C (AUTL1). Validated for ELISA, IF and IHC.
Application
ELISA, IF, IHC
Reactivity
Hu
Intended Use
Research Use Only
Guarantees
This antibody carries the LSBio 100% Guarantee. ✓
Category
Antibodies > Primary Antibodies > Polyclonal Antibodies
Alternative Names
AUTL3 | APG4-C | APG4C | AUTL1 | Autophagin-3 | APG4 autophagy 4 homolog C | ATG4C | Cysteine protease ATG4C
UniProt Number
Q96DT6
NCBI GenBank
NM_032852 | NP_116241.2
SwissProt
Q96DT6

Target

Target
Human AUTL1 / ATG4C
Antigen Species
Human
Epitope
Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy. Is not essential for autophagy development under normal conditions but is required for a proper autophagic response under stressful conditions such as prolonged starvation (By similarity). Cleaves the C-terminal amino acid of ATG8 family proteins MAP1LC3 and GABARAPL2, to reveal a C-terminal glycine. Exposure of the glycine at the C-terminus is essential for ATG8 proteins conjugation to phosphatidylethanolamine (PE) and insertion to membranes, which is necessary for autophagy. Has also an activity of delipidating enzyme for the PE-conjugated forms.
Gene Name
ATG4C

Antibody

Host Species
Rabbit
Clonality
Polyclonal
Isotype
IgG

Immunogen

Immunogen
Recombinant Human Cysteine protease ATG4C protein (419-448AA)
Immunogen Type
Recombinant Immunogen

Format

Conjugate/Label
Unconjugated
Format
Liquid
Formulation
PBS, pH 7.4, 0.03% Proclin 300, 50% glycerol.
Preservative
Yes
Purification Method
Protein G Affinity

Storage & Handling

Storage Conditions
Short term: -20°C; Long term: -80°C; Avoid freeze-thaw cycles.
Recommended Storage Buffer
PBS

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