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PathPlus™ Recombinant Monoclonal Mouse anti-Human POMC / Proopiomelanocortin Antibody (clone r57, N-Terminus, IHC)

Human Pituitary: Formalin-Fixed, Paraffin-Embedded (FFPE)

PathPlus™ Recombinant Monoclonal Mouse anti-Human POMC / Proopiomelanocortin Antibody (clone r57, N-Terminus, IHC)

Primary AntibodyLSBio Guarantee
Antibody:Mouse Recombinant Monoclonal
Applications:Enzyme-Linked Immunosorbent Assay, Immunohistochemistry (general), Immunohistochemistry, Paraffin
Reactivity:Human
Format:Liquid
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$536.00each
Catalog Number: LS-B16256-100

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Overview

Description
Proopiomelanocortin antibody LS-B16256 is an unconjugated mouse recombinant monoclonal antibody to human Proopiomelanocortin (POMC) (N-Terminus). Validated for ELISA and IHC.
Application
ELISA, IHC, IHC-P
Reactivity
Hu
Intended Use
Research Use Only
Guarantees
This product carries the LSBio 100% Guarantee. ✓
Category
Antibodies > Primary Antibodies > Recombinant Antibodies
Alternative Names
Alpha-MSH | ACTH | Adrenocorticotropin | Adrenocorticotropic hormone | Beta-LPH | CLIP | Gamma-MSH | Lipotropin gamma | LPH | Melanotropin alpha | Met-enkephalin | Melanotropin beta | NPP | POMC | Pro-ACTH-endorphin | Lipotropin beta | Melanotropin gamma | MSH | Proopiomelanocortin | Beta-endorphin | Beta-MSH | Gamma-LPH | POC | Pro-opiomelanocortin
Recommended Dilution: IHC-P
1:100
UniProt Number
P01189
NCBI GenBank
NM_000939 | NP_000930.1
SwissProt
P01189

Target

Target
POMC / Proopiomelanocortin
Antigen Species
Human
Specificity
ACTH (same as Corticotropin) is a 39 amino acid active peptide produced by the anterior pituitary. This MAb is specific to Synacthen (aa1-24 of ACTH) - does not react with CLIP (aa17-39 of ACTH). POMC (pro-opiomelanocortin or corticotropin-lipotropin) is a 267 amino acid polypeptide hormone precursor that goes through extensive, tissue-specific posttranslational processing by convertases. POMC is cleaved into ten hormone chains named NPP, ACTH, alpha-MSH (Melanocyte Stimulating Hormone), beta-MSH, gamma-MSH, CLIP (corticotropin-like intermediary peptide), Lipotropin-beta, Lipotropin-gamma, beta-endorphin and Met-enkephalin. ACTH is also produced by cells of immune system (T-cells, B-cells, and macrophages) in response to stimuli associated with stress. Anti-ACTH is a useful marker in classification of pituitary tumors and the study of pituitary disease. It reacts with ACTH-producing cells (corticotrophs). It also may react with other tumors (e.g. some small cell carcinomas of the lung) causing paraneoplastic syndromes by secreting ACTH.
Epitope
ACTH (same as Corticotropin) is a 39 amino acid active peptide produced by the anterior pituitary. This MAb is specific to Synacthen (aa1-24 of ACTH) - does not react with CLIP (aa17-39 of ACTH). POMC (pro-opiomelanocortin or corticotropin-lipotropin) is a 267 amino acid polypeptide hormone precursor that goes through extensive, tissue-specific posttranslational processing by convertases. POMC is cleaved into ten hormone chains named NPP, ACTH, alpha-MSH (Melanocyte Stimulating Hormone), beta-MSH, gamma-MSH, CLIP (corticotropin-like intermediary peptide), Lipotropin-beta, Lipotropin-gamma, beta-endorphin and Met-enkephalin. ACTH is also produced by cells of immune system (T-cells, B-cells, and macrophages) in response to stimuli associated with stress. Anti-ACTH is a useful marker in classification of pituitary tumors and the study of pituitary disease. It reacts with ACTH-producing cells (corticotrophs). It also may react with other tumors (e.g. some small cell carcinomas of the lung) causing paraneoplastic syndromes by secreting ACTH.
Gene Name
POMC

Antibody

Host Species
Mouse
Clonality
Recombinant Monoclonal
Clone
r57
Light Chain
Kappa Light Chain
Origin Species
Human

Immunogen

Immunogen
N-Terminus fragment of human ACTH conjugated to KLH. Antigen Molecular Weight: ACTH is ~5 kDa , and the POMC precursor is ~30 kDa . The molecular weight of POMC depends upon isoform variation and post-translational modifications.

Format

Conjugate/Label
Unconjugated
Format
Liquid
Formulation
10 mM PBS, 0.05% BSA, 0.05% Sodium Azide
Concentration
200 µg/mL
Animal Free
No
Carrier-Free
No
Preservative
Yes
Purification Method
Protein A/G Affinity

Storage & Handling

Storage Conditions
Store at 2°C to 8°C for up to 2 years.
Recommended Storage Buffer
10 mM PBS

Request SDS/MSDS

To request an SDS/MSDS form for this product, please contact our Technical Support department at: technical@vectorlabs.com.