LSBio
PathPlus™ Polyclonal Rabbit anti-Human GPR68 / OGR1 Antibody (C-Terminus, IHC)

Human Kidney: Formalin-Fixed, Paraffin-Embedded (FFPE)

PathPlus™ Polyclonal Rabbit anti-Human GPR68 / OGR1 Antibody (C-Terminus, IHC)

Primary AntibodyLSBio Guarantee
Antibody:Rabbit Polyclonal
Applications:Immunohistochemistry (general)
Reactivity:Bovine, Hamster, Horse, Human, Mouse, Non-Human Primate, Pig, Rabbit, Rat
Format:Liquid
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$449.00each
Catalog Number: LS-A1194-50

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Overview

Description
OGR1 antibody LS-A1194 is an unconjugated rabbit polyclonal antibody to OGR1 (GPR68) (C-Terminus) from human. It is reactive with human, mouse, rat and other species. Validated for ICC, IF and IHC. Cited in 3 publications.
Application
IHC
Reactivity
Bov, Ham, Hr, Hu, Ms, NHP, Por, Rb, Rt
Intended Use
Research Use Only
Guarantees
This product carries the LSBio 100% Guarantee.
Category
Antibodies > Primary Antibodies > Polyclonal Antibodies
Alternative Names
Brgrb | G protein-coupled receptor 68 | GPR68 | G-protein coupled receptor 68 | OGR1 | Brgr1 | GPR12A | OGR-1 | gpr12a
Recommended Dilution: IHC-P
4 µg/ml
UniProt Number
Q15743
SwissProt
Q15743

Target

Target
GPR68 / OGR1
Antigen Species
Human
Specificity
Human GPR68. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
Epitope
Human GPR68. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
Gene Name
GPR68

Antibody

Host Species
Rabbit
Clonality
Polyclonal

Immunogen

Immunogen
Synthetic 16 amino acid peptide from C-Terminus of human GPR68. Percent identity with other species by BLAST analysis: Human, Gorilla, Gibbon, Monkey, Marmoset, Mouse, Rat, Bovine, Hamster, Elephant, Horse, Rabbit, Pig (100%); Dog, Bat, Panda, Platypus (88%).
Immunogen Type
Synthetic Peptide (Linear)

Format

Conjugate/Label
Unconjugated
Format
Liquid
Formulation
PBS, 0.1% Sodium Azide
Concentration
1 mg/mL
Animal Free
No
Carrier-Free
Yes
Preservative
Yes
Purification Method
Affinity Purified

Storage & Handling

Storage Conditions
Aliquot and store undiluted at -20°C or below for up to 1 year. Can be stored undiluted at 4°C for up to 1 month. Avoid freeze-thaw cycles.
Recommended Storage Buffer
PBS

Proton-sensing G-protein-coupled receptors. Ludwig MG, Vanek M, Guerini D, Gasser JA, Jones CE, Junker U, Hofstetter H, Wolf RM, Seuwen K. Nature. 2003;425:93-8.

PubMed: 12955148


Convergent signaling by acidosis and receptor activator of NF-kappaB ligand (RANKL) on the calcium/calcineurin/NFAT pathway in osteoclasts. Komarova SV, Pereverzev A, Shum JW, Sims SM and Dixon SJ. Proceedings of the National Academy of Sciences of the United States of America. 2005;102:2643-8.

PubMed: 15695591 · PMC: PMC548977


Expression of and role for ovarian cancer G-protein coupled receptor 1 (OGR1) during osteoclastogenesis. Yang M, Mailhot G, Birnbaum MJ, Mackay CA, Mason-Savas A and Odgren PR. The Journal of biological chemistry. 2006;281:23598-605.

PubMed: 16787916


Mutations in the pH-Sensing G-protein-Coupled Receptor GPR68 Cause Amelogenesis Imperfecta. Parry DA, Smith CE, El-Sayed W, Poulter JA, Shore RC, Logan CV, Mogi C, Sato K, Okajima F, Harada A, Zhang H, Koruyucu M, Seymen F, Hu JC, Simmer JP, Ahmed M, Jafri H, Johnson CA, Inglehearn CF, Mighell AJ. American journal of human genetics. 2016 October;99:984-990.

PubMed: 27693231 · PMC: PMC5065684

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