Monoclonal Rat anti-Rat BAFF / TNFSF13B Antibody (Biotin)
Catalog Number: LS-C12084-100
100 µg / $943.00
Antibody: Rat Monoclonal
Applications: Enzyme-Linked Immunosorbent Assay, Flow Cytometry
Reactivity: Mouse, Rat
Format: Liquid
Tim-3 transfected LY5178Y cells stained with Rat anti-Mouse TIM-3
Monoclonal Rat anti-Mouse HAVCR2 / TIM-3 Antibody (clone RMT3-23, IHC, IF)
Primary AntibodyLSBio Guarantee
| Antibody: | Rat Monoclonal |
| Applications: | Flow Cytometry, Immunofluorescence, Immunohistochemistry (general), Immunohistochemistry, Frozen, Immunohistochemistry, Paraffin |
| Reactivity: | Mouse |
| Format: | Liquid |
$286.00each
Catalog Number: LS-C187577-0.1
Catalog Number: LS-C187577
For bulk orders or custom formulations:
Request a QuoteOverview
- Description
- TIM-3 antibody LS-C187577 is an unconjugated rat monoclonal antibody to mouse TIM-3 (HAVCR2). Validated for Flow, IF and IHC.
- Application
- FC, IF, IHC, IHC-F, IHC-P
- Reactivity
- Ms
- Intended Use
- Research Use Only
- Guarantees
- This antibody carries the LSBio 100% Guarantee. ✓
- Category
- Antibodies > Primary Antibodies > Monoclonal Antibodies
- Alternative Names
- HAVcr-2 | KIM-3 | Kidney injury molecule-3 | T cell immunoglobulin mucin 3 | Tim-3 | TIMD3 | T-cell membrane protein 3 | TIM3 | TIMD-3 | HAVCR2 | T cell immunoglobulin mucin-3 | CD366
- Recommended Dilution: FC
- 1:25 - 1:200
- UniProt Number
- Q8TDQ0
- NCBI GenBank
- NM_032782 | NP_116171.3
- SwissProt
- Q8TDQ0
Target
- Target
- Mouse HAVCR2 / TIM-3
- Antigen Species
- Mouse
- Epitope
- Rat anti Mouse Tim-3 clone RMT3-23 specifically recognizes mouse T-cell immunoglobulin mucin 3, a transmembrane glycoprotein and member of the immunoglobulin superfamily, preferentially expressed by differentiated CD4+ Th1 cells and CD8+ Tc1 (cytotoxic) cells, but not by CD4+ Th2 cells or CD8+ Tc2 cells. Tim-3 acts as a negative regulator of Th1-mediated inflammatory diseases including GVHD, type I diabetes, and EAE (experimental autoimmune encephalomyelitis), promotes immunological tolerance, and is a receptor for galectin-9, shown to induce cell death of Th1 cells in vitro. Tim-3 is also involved in the regulation of macrophage activation, acts as a phagocytic receptor, and has been shown to recognize apoptotic cells via the IgV domain. Studies have shown that clone RMT3-23 significantly inhibits the efficient phagocytosis of apoptotic cells by PEMs (peritoneal exudate Mac1+ cells) see for details.
- Gene Name
- HAVCR2
Antibody
- Host Species
- Rat
- Clonality
- Monoclonal
- Clone
- RMT3-23
- Isotype
- IgG2a
Format
- Conjugate/Label
- Unconjugated
- Format
- Liquid
- Formulation
- PBS, 0.09% Sodium Azide
- Concentration
- 1 mg/mL
- Preservative
- Yes
- Purification Method
- Protein G Affinity
Storage & Handling
- Storage Conditions
- Store at 4°C or at -20°C. Store undiluted. Avoid freeze-thaw cycles. Microcentrifugation recommended if solution contains precipitate.
- Recommended Storage Buffer
- PBS
