LSBio
Monoclonal Mouse anti-Human Complement C3c Antibody (clone 10-02A, IHC, WB)

Monoclonal Mouse anti-Human Complement C3c Antibody (clone 10-02A, IHC, WB)

Primary AntibodyLSBio Guarantee
Antibody:Mouse Monoclonal
Applications:Enzyme-Linked Immunosorbent Assay, Flow Cytometry, Immunohistochemistry (general), Immunohistochemistry, Frozen, Western Blot
Reactivity:Human
Format:Liquid
See all Human Complement C3c antibodies →
$540.00each
Catalog Number: LS-C44974-0.1

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Overview

Description
Complement C3c antibody LS-C44974 is an unconjugated mouse monoclonal antibody to human Complement C3c. Validated for ELISA, Flow, IHC and WB.
Application
ELISA, FC, IHC, IHC-F, WB
Reactivity
Hu
Intended Use
Research Use Only
Guarantees
This antibody carries the LSBio 100% Guarantee. ✓
Category
Antibodies > Primary Antibodies > Monoclonal Antibodies

Target

Target
Human Complement C3c
Antigen Species
Human
Epitope
Recognizes 135kD complement component 3c (C3c), present in blood serum. C3c is generated over the course of complement activation, where convertase C4b2a (classical pathway) and convertase C3bBb (alternative pathway) cleave C3 to C3b and C3a. C3b is further degraded into iC3b and C3dg/C3d. iC3b is then slowly cleaved (possibly by factor I) to form C3c (beta chain + alpha chain fragment 1 + alpha chain fragment 2), C3dg and C3f. C3 is crucial in the induction of tolerance generated when an antigen is introduced into immunoprivileged sites and this is exploited by pathogens and cancer cells to evade the immune system by inhibiting complement activation. Binds both C3c and C3 and so is not suitable for all ELISA applications.

Antibody

Host Species
Mouse
Clonality
Monoclonal
Clone
10-02A
Isotype
IgG1

Immunogen

Immunogen
Native human C3 from normal serum, highly purified by chromatography.
Immunogen Type
Native Protein (Purified from Natural Source)

Format

Conjugate/Label
Unconjugated
Format
Liquid
Formulation
BBS, 0.1% Sodium Azide
Concentration
1.2 mg/mL
Preservative
Yes
Purification Method
Protein A Affinity

Storage & Handling

Storage Conditions
Short term: store at 4°C. Long term: aliquot and store at -20°C. Avoid freeze-thaw cycles.
Recommended Storage Buffer
bbs

Request SDS/MSDS

To request an SDS/MSDS form for this product, please contact our Technical Support department at: technical@vectorlabs.com.