LIME1 / LIME Antibody (aa281-296, clone LIME-10, Concentrated)
Primary AntibodyLSBio Guarantee
| Antibody: | Mouse Monoclonal |
| Applications: | Western Blot |
| Reactivity: | Human |
| Format: | Liquid |
$556.00each
Catalog Number: LS-C204122-0.1
Catalog Number: LS-C204122
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- Description
- LIME antibody LS-C204122 is an unconjugated mouse monoclonal antibody to human LIME (LIME1) (aa281-296). Validated for WB.
- Application
- WB
- Reactivity
- Hu
- Intended Use
- Research Use Only
- Guarantees
- This antibody carries the LSBio 100% Guarantee. ✓
- Category
- Antibodies > Primary Antibodies > Monoclonal Antibodies
- Alternative Names
- DJ583P15.4 | LIME1 | Lck-interacting molecule | LIME | RP4-583P15.5 | LP8067
- UniProt Number
- Q9H400
- NCBI GenBank
- NM_017806 | NP_060276.2
- SwissProt
- Q9H400
Target
- Target
- Human LIME1 / LIME
- Antigen Species
- Human
- Epitope
- LIME (Lck-interacting molecule) is a new raft-associated adaptor protein involved in regulation of T cell activation by coreceptors. LIME becomes tyrosine phosphorylated after cross-linking of the CD4 or CD8 coreceptors. Phospho-LIME associates with the Src family kinase Lck and its negative regulator, Csk. Ectopic expression of LIME in Jurkat T cells results in an increase of Csk in lipid rafts, increased phosphorylation of Lck and higher Ca2+ response to CD3 stimulation.
- Gene Name
- LIME1
Antibody
- Host Species
- Mouse
- Clonality
- Monoclonal
- Clone
- LIME-10
- Isotype
- IgG2a
Immunogen
- Immunogen
- COOH-terminal peptide comprising residues 281-296 of the human LIME conjugated to keyhole limpet hemocyanin
- Immunogen Type
- Peptide
Format
- Conjugate/Label
- Unconjugated
- Format
- Liquid
- Formulation
- PBS, pH 7.4, 15 mM Sodium Azide
- Concentration
- 1 mg/mL
- Preservative
- Yes
- Purification Method
- Other
Storage & Handling
- Storage Conditions
- Store at 2-8°C.
- Recommended Storage Buffer
- PBS