KLRK1 / CD314 / NKG2D Antibody (clone 1D11, Low Endotoxin)
Primary AntibodyLSBio Guarantee
| Antibody: | Mouse Monoclonal |
| Applications: | Flow Cytometry, Immunohistochemistry, Frozen, Immunoprecipitation |
| Reactivity: | Human |
| Format: | Liquid |
$654.00each
Catalog Number: LS-C44804-0.5
Catalog Number: LS-C44804
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- Description
- NKG2D antibody LS-C44804 is an unconjugated mouse monoclonal antibody to human NKG2D (KLRK1 / CD314). Validated for Flow, IHC and IP.
- Application
- FC, IHC-F, IP
- Reactivity
- Hu
- Intended Use
- Research Use Only
- Guarantees
- This antibody carries the LSBio 100% Guarantee. ✓
- Category
- Antibodies > Primary Antibodies > Monoclonal Antibodies
- Alternative Names
- D12S2489E | CD314 antigen | KLR | KLRK1 | NK cell receptor D | NKG2D | NKG2-D | NKG2-D-activating NK receptor | CD314
- Recommended Dilution: FC
- 1:50 - 1:200
- UniProt Number
- P26718
- NCBI GenBank
- NM_007360 | NP_031386.2
- SwissProt
- P26718
Target
- Target
- Human KLRK1 / CD314 / NKG2D
- Antigen Species
- Human
- Epitope
- Specific for CD314, also known as natural killer receptor G2 (NKG2D) and as killer cell lectin-like receptor subfamily K, member 1 (KLRK1). CD314 is a C-type lectin-like activating receptor which is expressed on most natural killer (NK) cells, CD8 T cells and gamma delta T cells. CD314 forms homodimers that signal through an associated DAP10 adaptor protein. Ligands of CD314 include MICA, MICB and UL16 binding protein (ULBP), which are inducibly expressed. Ligand binding to CD314 results in NK cell activation and potent costimulation of effector T cells. Clone 1D11 is reported to inhibit T cell recognition of MICA (1,6).
- Gene Name
- KLRC4-KLRK1|KLRK1
Antibody
- Host Species
- Mouse
- Clonality
- Monoclonal
- Clone
- 1D11
- Isotype
- IgG1
Immunogen
- Immunogen
- NKL cells
- Immunogen Type
- Cell-Based Immunization
Format
- Conjugate/Label
- Unconjugated
- Format
- Liquid
- Formulation
- PBS
- Concentration
- 1 mg/mL
- Preservative
- No
- Purification Method
- Protein G Affinity
Storage & Handling
- Storage Conditions
- Store at -20°C. Do not use frost-free freezers. Avoid freeze-thaw cycles. Microcentrifugation recommended if solution contains precipitate.
- Recommended Storage Buffer
- PBS