Anti-KLB antibody IHC of human colon. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
KLB / Beta Klotho Antibody (Internal)
| Antibody: | Rabbit Polyclonal |
| Applications: | Immunohistochemistry (general), Immunohistochemistry, Paraffin, Western Blot |
| Reactivity: | Human |
| Format: | Liquid |
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- Description
- Beta Klotho antibody LS-B3568 is an unconjugated rabbit polyclonal antibody to human Beta Klotho (KLB) (Internal). Validated for IHC and WB. Cited in 5 publications.
- Application
- IHC, IHC-P, WB
- Reactivity
- Hu
- Intended Use
- Research Use Only
- Guarantees
- This product carries the LSBio 100% Guarantee. ✓
- Category
- Antibodies > Primary Antibodies > Polyclonal Antibodies
- Alternative Names
- BetaKlotho | Beta-klotho | BKL | KLB | Klotho beta | Klotho beta like | Klotho beta-like protein
- Recommended Dilution: IHC-P
- 10 µg/ml
- Recommended Dilution: WB
- 0.5 µg/ml
- UniProt Number
- Q86Z14
- SwissProt
- Q86Z14
Target
- Target
- KLB / Beta Klotho
- Antigen Species
- Human
- Specificity
- bovine, human, mouse, rat KLB
- Epitope
- Human KLB
- Gene Name
- KLB
Antibody
- Host Species
- Rabbit
- Clonality
- Polyclonal
- Origin Species
- Human
Immunogen
- Immunogen
- Synthetic peptide from internal region of human KLB (NP_783864.1, Q86Z14). Percent identity by BLAST analysis: Human (100%); Dog, Horse (92%); Rabbit, Chicken (85%); Guinea pig (84%).
- Immunogen Type
- Synthetic Peptide (Linear)
Format
- Conjugate/Label
- Unconjugated
- Format
- Liquid
- Formulation
- PBS, 0.09% sodium azide, 2% sucrose
- Concentration
- 0.5 mg/mL
- Volume
- 50 Microliter
- Animal Free
- No
- Carrier-Free
- Yes
- Preservative
- Yes
- Purification Method
- Affinity Purified
Storage & Handling
- Storage Conditions
- Short term: Store at 2-8°C. Long term: Aliquot and store at -20°C. Avoid freeze/thaw cycles.
- Recommended Storage Buffer
- PBS
Screen for small molecules increasing the mitochondrial membrane potential. Montague CR, Fitzmaurice A, Hover BM, Salazar NA, Fey JP. Journal of biomolecular screening. 2014 Mar;19:387-98.
PubMed: 23867716
MicroRNA 34a inhibits beige and brown fat formation in obesity in part by suppressing adipocyte fibroblast growth factor 21 signaling and SIRT1 function. Fu T, Seok S, Choi S, Huang Z, Suino-Powell K, Xu HE, Kemper B, Kemper JK. Molecular and cellular biology. Nov;34:4130-42.
PubMed: 25182532 · PMC: PMC4248715
Aberrantly elevated microRNA-34a in obesity attenuates hepatic responses to FGF19 by targeting a membrane coreceptor beta -Klotho. Fu T, Choi SE, Kim DH, Seok S, Suino-Powell KM, Xu HE, Kemper JK. Proceedings of the National Academy of Sciences of the United States of America. Oct;109:16137-42.
PubMed: 22988100 · PMC: PMC3479576
Ileal Transposition Surgery Decreases Fat Mass and Improves Glucose Metabolism in Diabetic GK Rats: Possible Involvement of FGF21. Yan K, Chen W, Zhu H, Lin G, Pan H, Li N, Wang L, Yang H, Liu M, Gong F. Frontiers in physiology. 2018 March;9:191.
PubMed: 29593555 · PMC: PMC5854974
Hypocaloric Diet Prevents the Decrease in FGF21 Elicited by High Phosphorus Intake. Pineda C, Rios R, Raya AI, Rodriguez M, Aguilera-Tejero E, Lopez I. Nutrients. 2018 October;10:pii E1496.
PubMed: 30322116 · PMC: PMC6213303