LSBio
ITGAV/Integrin Alpha V/CD51 Antibody (clone NKI-M7 (former AMF7))

ITGAV/Integrin Alpha V/CD51 Antibody (clone NKI-M7 (former AMF7))

Primary AntibodyLSBio Guarantee
Antibody:Mouse Monoclonal
Applications:Enzyme-Linked Immunosorbent Assay, Flow Cytometry, Immunohistochemistry (general), Immunohistochemistry, Frozen, Immunoprecipitation
Reactivity:Human
Format:Liquid
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$433.00each
Catalog Number: LS-C347518-0.1

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Overview

Description
CD51 antibody LS-C347518 is an unconjugated mouse monoclonal antibody to human CD51 (ITGAV / Integrin Alpha V). Validated for ELISA, Flow, IHC and IP.
Application
ELISA, FC, IHC, IHC-F, IP
Reactivity
Hu
Intended Use
Research Use Only
Guarantees
This antibody carries the LSBio 100% Guarantee. ✓
Category
Antibodies > Primary Antibodies > Monoclonal Antibodies
Alternative Names
CD51 | CD51 antigen | Integrin, alpha V | MSK8 | Integrin Alpha V | Integrin alpha-V | ITGAV | VNRA | Vitronectin receptor | Integrin alphaVbeta3 | VTNR
UniProt Number
P06756
NCBI GenBank
NM_002210 | NP_002201.1
SwissProt
P06756

Target

Target
Human ITGAV/Integrin Alpha V/CD51
Antigen Species
Human
Epitope
T-lymphocyte clones NKI-M7 detect a melanoma-associated proteoglycan (MW greater than 450-250 kD) and a molecular complex, which under reducing conditions consists of 4 compounds of 120, 95, 29 and 25 kD respectively. NKI-M7 reacts with cultured melanomas melanomas in frozen sections. The antigen detected by NKI-M7 is strongly associated with the adhesion and cytoplasmic spreading of melanoma cells to plastic surfaces and monolayers of vascular endothelial cells. NKI-M7 blocks fibronectin-induced chemotactic motility and chemokinesis of melanoma cells. In addition to their membrane localization, the antigens detected by NKI-M7are abundant in extracellular adhesion plaques deposited by cultured melanoma cells. NKI-M7 stains primary tumors heterogeneously, whereas metastases are homogeneously stained.
Gene Name
ITGAV

Antibody

Host Species
Mouse
Clonality
Monoclonal
Clone
NKI-M7 (former AMF7)
Isotype
IgG1

Immunogen

Immunogen
NKI-M7 is a Mouse monoclonal IgG1 antibody derived by fusion of SP2/0 Mouse myeloma cells with spleen cells from a BALB/c Mouse immunized with cultured melanoma cells derived from a Human melanoma metastasis.
Immunogen Type
Fusion Protein (e.g., GST, MBP tag)

Format

Conjugate/Label
Unconjugated
Format
Liquid
Formulation
PBS, 0.09% Sodium Azide
Concentration
1 mg/mL
Preservative
Yes
Purification Method
Other

Storage & Handling

Storage Conditions
Short term: store at 4°C. Long term: aliquot and store at -20°C. Avoid freeze-thaw cycles.
Recommended Storage Buffer
PBS

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To request an SDS/MSDS form for this product, please contact our Technical Support department at: technical@vectorlabs.com.