Anti-H2AX antibody IHC of human placenta. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.

IHC-plus™ H2AFX / H2AX Antibody (C-Terminus)

Primary AntibodyLSBio Guarantee

Antibody:	Rabbit Polyclonal
Applications:	Immunofluorescence, Immunohistochemistry (general), Immunohistochemistry, Paraffin, Western Blot
Reactivity:	Human
Format:	Liquid

$383.00each

Catalog Number: LS-B3282-50

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Overview

Description: H2AX antibody LS-B3282 is an unconjugated rabbit polyclonal antibody to human H2AX (H2AFX) (C-Terminus). Validated for IF, IHC and WB. Tested on 20 paraffin-embedded human tissues.
Application: IF, IHC, IHC-P, WB
Reactivity: Hu
Intended Use: Research Use Only
Guarantees: This product carries the LSBio 100% Guarantee. ✓
Category: Antibodies > Primary Antibodies > Polyclonal Antibodies
Alternative Names: H2AFX | H2AX | Histone H2A.x | H2A.X | H2A histone family, member X | H2AX histone
Recommended Dilution: IF/ICC: 1:400 - 1:800
Recommended Dilution: IHC-P: 2.5 µg/ml
UniProt Number: P16104
NCBI GenBank: NM_002105 | NP_002096.1
SwissProt: P16104

Target

Target: H2AFX / H2AX
Antigen Species: Human
Specificity: Specific for human histone H2AX. H2AX comprises approximately 2-25% of the histone H2A pool in mammalian cells. The extended C-terminal tail of H2AX contains a serine (Ser139) embedded in an conserved SQE motif, which is rapidly phosphorylated at sites of double strand breaks and stalled replication forks. Phosphorylated H2AX may serve to recruit other repair proteins to the site of DNA damage. H2AX has been implicated in both homologous recombination and nonhomologous end joining DNA repair pathways
Epitope: Recognizes human histone H2AX. H2AX comprises approximately 2-25% of the histone H2A pool in mammalian cells. The extended C-terminal tail of H2AX contains a serine (Ser139) embedded in an conserved SQE motif, which is rapidly phosphorylated at sites of double strand breaks and stalled replication forks. Phosphorylated H2AX may serve to recruit other repair proteins to the site of DNA damage. H2AX has been implicated in both homologous recombination and nonhomologous end joining DNA repair pathways.
Gene Name: H2AX