LSBio
IHC-plus™ DDR2 Antibody

Immunohistochemistry of paraffin-embedded human heart tissue using DDR2 Antibody at dilution of 1:100

IHC-plus™ DDR2 Antibody

Primary AntibodyLSBio Guarantee
Antibody:Rabbit Polyclonal
Applications:Enzyme-Linked Immunosorbent Assay, Immunofluorescence, Immunohistochemistry (general), Immunohistochemistry, Paraffin, Western Blot
Reactivity:Human, Mouse
Format:Liquid
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$470.00each
Catalog Number: LS-B15752-50

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Overview

Description
DDR2 antibody LS-B15752 is an unconjugated rabbit polyclonal antibody to DDR2 from human. It is reactive with human and mouse. Validated for ELISA, IF, IHC and WB. Tested on 20 paraffin-embedded human tissues. Cited in 2 publications.
Application
ELISA, IF, IHC, IHC-P, WB
Reactivity
Hu, Ms
Intended Use
RUO
Guarantees
This product carries the LSBio 100% Guarantee. ✓
Category
Antibodies > Primary Antibodies > Polyclonal Antibodies
Alternative Names
DDR2 | CD167b antigen | Discoidin domain receptor 2 | Hydroxyaryl-protein kinase | MIG20a | Tyrosine-protein kinase TYRO10 | NTRKR3 | TYRO10 | Tyrosylprotein kinase
Recommended Dilution: IF/ICC
1:50 - 1:200
Recommended Dilution: IHC-P
10 µg/ml
Recommended Dilution: WB
1:500 - 1:5000
UniProt Number
Q16832
NCBI GenBank
NM_006182, NP_006173.2
SwissProt
Q16832

Target

Target
DDR2
Antigen Species
Hu
Specificity
Tyrosine kinase that functions as cell surface receptor for fibrillar collagen and regulates cell differentiation, remodeling of the extracellular matrix, cell migration and cell proliferation. Required for normal bone development. Regulates osteoblast differentiation and chondrocyte maturation via a signaling pathway that involves MAP kinases and leads to the activation of the transcription factor RUNX2. Regulates remodeling of the extracellular matrix by up-regulation of the collagenases MMP1, MMP2 and MMP13, and thereby facilitates cell migration and tumor cell invasion. Promotes fibroblast migration and proliferation, and thereby contributes to cutaneous wound healing.
Epitope
Tyrosine kinase that functions as cell surface receptor for fibrillar collagen and regulates cell differentiation, remodeling of the extracellular matrix, cell migration and cell proliferation. Required for normal bone development. Regulates osteoblast differentiation and chondrocyte maturation via a signaling pathway that involves MAP kinases and leads to the activation of the transcription factor RUNX2. Regulates remodeling of the extracellular matrix by up-regulation of the collagenases MMP1, MMP2 and MMP13, and thereby facilitates cell migration and tumor cell invasion. Promotes fibroblast migration and proliferation, and thereby contributes to cutaneous wound healing.
Gene Name
DDR2

Antibody

Host Species
Rb
Clonality
Polyclonal
Origin Species
Hu

Immunogen

Immunogen
Recombinant Human Discoidin domain-containing receptor 2 protein (447-540AA)

Format

Conjugate/Label
Unconj
Format
Liquid
Formulation
PBS, pH 7.4, 0.03% Proclin 300, 50% glycerol.
Animal Free
No
Carrier-Free
Yes
Preservative
Yes
Purification Method
Prot G

Storage & Handling

Storage Conditions
Short term: store at -20°C. Long term: store at -80°C. Avoid freeze-thaw cycles.
Recommended Storage Buffer
PBS
The collagen receptor, discoidin domain receptor 2, functions in Gli1-positive skeletal progenitors and chondrocytes to control bone development. Fatma F Mohamed, Chunxi Ge, Randy T Cowling, Daniel Lucas, Shawn A Hallett, Noriaki Ono, Abdul-Aziz Binrayes, Barry Greenberg, Renny T Franceschi. Bone research. 2022 February;10:11. PubMed: 35140200 PMC: PMC8828874
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