DDR2 Antibody
Catalog Number: LS-C485841-100
100 µL / $309.00
Antibody: Rabbit Polyclonal
Applications: Enzyme-Linked Immunosorbent Assay
Reactivity: Rhesus Macaque
Format: Liquid
Immunohistochemistry of paraffin-embedded human heart tissue using DDR2 Antibody at dilution of 1:100
IHC-plus™ DDR2 Antibody
Primary AntibodyLSBio Guarantee
| Antibody: | Rabbit Polyclonal |
| Applications: | Enzyme-Linked Immunosorbent Assay, Immunofluorescence, Immunohistochemistry (general), Immunohistochemistry, Paraffin, Western Blot |
| Reactivity: | Human, Mouse |
| Format: | Liquid |
$470.00each
Catalog Number: LS-B15752-50
Catalog Number: LS-B15752
For bulk orders or custom formulations:
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- Description
- DDR2 antibody LS-B15752 is an unconjugated rabbit polyclonal antibody to DDR2 from human. It is reactive with human and mouse. Validated for ELISA, IF, IHC and WB. Tested on 20 paraffin-embedded human tissues. Cited in 2 publications.
- Application
- ELISA, IF, IHC, IHC-P, WB
- Reactivity
- Hu, Ms
- Intended Use
- Research Use Only
- Guarantees
- This product carries the LSBio 100% Guarantee. ✓
- Category
- Antibodies > Primary Antibodies > Polyclonal Antibodies
- Alternative Names
- DDR2 | CD167b antigen | Discoidin domain receptor 2 | Hydroxyaryl-protein kinase | MIG20a | Tyrosine-protein kinase TYRO10 | NTRKR3 | TYRO10 | Tyrosylprotein kinase
- Recommended Dilution: IF/ICC
- 1:50 - 1:200
- Recommended Dilution: IHC-P
- 10 µg/ml
- Recommended Dilution: WB
- 1:500 - 1:5000
- UniProt Number
- Q16832
- NCBI GenBank
- NM_006182 | NP_006173.2
- SwissProt
- Q16832
Target
- Target
- DDR2
- Antigen Species
- Human
- Specificity
- Tyrosine kinase that functions as cell surface receptor for fibrillar collagen and regulates cell differentiation, remodeling of the extracellular matrix, cell migration and cell proliferation. Required for normal bone development. Regulates osteoblast differentiation and chondrocyte maturation via a signaling pathway that involves MAP kinases and leads to the activation of the transcription factor RUNX2. Regulates remodeling of the extracellular matrix by up-regulation of the collagenases MMP1, MMP2 and MMP13, and thereby facilitates cell migration and tumor cell invasion. Promotes fibroblast migration and proliferation, and thereby contributes to cutaneous wound healing.
- Epitope
- Tyrosine kinase that functions as cell surface receptor for fibrillar collagen and regulates cell differentiation, remodeling of the extracellular matrix, cell migration and cell proliferation. Required for normal bone development. Regulates osteoblast differentiation and chondrocyte maturation via a signaling pathway that involves MAP kinases and leads to the activation of the transcription factor RUNX2. Regulates remodeling of the extracellular matrix by up-regulation of the collagenases MMP1, MMP2 and MMP13, and thereby facilitates cell migration and tumor cell invasion. Promotes fibroblast migration and proliferation, and thereby contributes to cutaneous wound healing.
- Gene Name
- DDR2
Antibody
- Host Species
- Rabbit
- Clonality
- Polyclonal
- Origin Species
- Human
Immunogen
- Immunogen
- Recombinant Human Discoidin domain-containing receptor 2 protein (447-540AA)
Format
- Conjugate/Label
- Unconjugated
- Format
- Liquid
- Formulation
- PBS, pH 7.4, 0.03% Proclin 300, 50% glycerol.
- Animal Free
- No
- Carrier-Free
- Yes
- Preservative
- Yes
- Purification Method
- Protein G Affinity
Storage & Handling
- Storage Conditions
- Short term: store at -20°C. Long term: store at -80°C. Avoid freeze-thaw cycles.
- Recommended Storage Buffer
- PBS
The collagen receptor, discoidin domain receptor 2, functions in Gli1-positive skeletal progenitors and chondrocytes to control bone development. Fatma F Mohamed, Chunxi Ge, Randy T Cowling, Daniel Lucas, Shawn A Hallett, Noriaki Ono, Abdul-Aziz Binrayes, Barry Greenberg, Renny T Franceschi. Bone research. 2022 February;10:11.
PubMed: 35140200 · PMC: PMC8828874
Synthetic peptides activating discoidin domain receptor 2 and collagen-binding integrins cooperate to stimulate osteoblast differentiation of skeletal progenitor cells. Chunxi Ge, Yiming Li, Fashuai Wu, Peter Ma, Renny T Franceschi. Acta biomaterialia. 2023 August;166:109-118.
PubMed: 37245640 · PMC: PMC10643765
