Human Kidney: Formalin-Fixed, Paraffin-Embedded (FFPE)

IHC-plus™ CDH16 / Cadherin 16 Antibody (clone CDH16/1532R)

Primary AntibodyLSBio Guarantee

Antibody:	Rabbit Recombinant Monoclonal
Applications:	Flow Cytometry, Immunohistochemistry (general), Immunohistochemistry, Paraffin, Western Blot
Reactivity:	Human
Format:	Liquid

$470.00each

Catalog Number: LS-B16272-50

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Overview

Description: Cadherin 16 antibody LS-B16272 is an unconjugated rabbit recombinant monoclonal antibody to human Cadherin 16 (CDH16). Validated for Flow, IHC and WB. Tested on 20 paraffin-embedded human tissues.
Application: FC, IHC, IHC-P, WB
Reactivity: Hu
Intended Use: Research Use Only
Guarantees: This product carries the LSBio 100% Guarantee. ✓
Category: Antibodies > Primary Antibodies > Recombinant Antibodies
Alternative Names: Cadherin 16, KSP-cadherin | Cadherin 16 | Cadherin-16 | CDH16 | Kidney-specific cadherin | KSP-cadherin
Recommended Dilution: FC: 1 - 2 µg/10E6 cells
Recommended Dilution: IHC-P: 1:100
Recommended Dilution: WB: 1 - 2 µg/ml
UniProt Number: O75309
NCBI GenBank: NM_004062 | NP_004053.1
SwissProt: O75309

Target

Target: CDH16 / Cadherin 16
Antigen Species: Human
Specificity: This MAb recognizes a protein of 130 kDa , identified as Ksp-cadherin. Cadherins form a superfamily of related glycoproteins that mediate calcium-dependent cell adhesion and transmit signals from the extracellular matrix to the cytoplasm. Cadherins have been implicated in embryogenesis, tissue morphogenesis, tissue structure maintenance, cell polarization, neoplastic invasiveness and metastasis, and membrane transport. It is suggested that Ksp-cadherin is a marker for terminal differentiation of the basolateral membranes of renal tubular epithelial cells. Within the kidney, Ksp-Cadherin is found exclusively in the basolateral membrane of renal tubular epithelial cells and collecting duct cells, and not in glomeruli, renal interstitial cells, or blood vessels. Ksp-Cadherin has been suggested to distinguish Chromophobe Renal-Cell Carcinoma from Oncocytoma.
Epitope: This MAb recognizes a protein of 130 kDa , identified as Ksp-cadherin. Cadherins form a superfamily of related glycoproteins that mediate calcium-dependent cell adhesion and transmit signals from the extracellular matrix to the cytoplasm. Cadherins have been implicated in embryogenesis, tissue morphogenesis, tissue structure maintenance, cell polarization, neoplastic invasiveness and metastasis, and membrane transport. It is suggested that Ksp-cadherin is a marker for terminal differentiation of the basolateral membranes of renal tubular epithelial cells. Within the kidney, Ksp-Cadherin is found exclusively in the basolateral membrane of renal tubular epithelial cells and collecting duct cells, and not in glomeruli, renal interstitial cells, or blood vessels. Ksp-Cadherin has been suggested to distinguish Chromophobe Renal-Cell Carcinoma from Oncocytoma.
Gene Name: CDH16