Immunohistochemistry of paraffin-embedded human pancreatic tissue using FZD4 Antibody at dilution of 1:100
FZD4 / Frizzled 4 Antibody
Primary AntibodyLSBio Guarantee
| Antibody: | Rabbit Polyclonal |
| Applications: | Enzyme-Linked Immunosorbent Assay, Immunofluorescence, Immunohistochemistry (general) |
| Reactivity: | Human |
| Format: | Liquid |
$300.00each
Catalog Number: LS-C502091-50
Catalog Number: LS-C502091
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- Description
- Frizzled 4 antibody LS-C502091 is an unconjugated rabbit polyclonal antibody to human Frizzled 4 (FZD4). Validated for ELISA, IF and IHC.
- Application
- ELISA, IF, IHC
- Reactivity
- Hu
- Intended Use
- Research Use Only
- Guarantees
- This antibody carries the LSBio 100% Guarantee. ✓
- Category
- Antibodies > Primary Antibodies > Polyclonal Antibodies
- Alternative Names
- CD344 | CD344 antigen | EVR1 | FZD4 | Frizzled family receptor 4 | Frizzled-4 | Fz-4 | Fz4 | HFz4 | Exudative vitreoretinopathy 1 | FEVR | FZD4S | FzE4 | Frizzled 4 | Frizzled homolog 4 | WNT receptor frizzled-4
- UniProt Number
- Q9ULV1
- NCBI GenBank
- NM_012193 | NP_036325.2
- SwissProt
- Q9ULV1
Target
- Target
- Human FZD4 / Frizzled 4
- Antigen Species
- Human
- Epitope
- Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin (CTNNB1) canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin (CTNNB1) and activation of Wnt target genes. Plays a critical role in retinal vascularization by acting as a receptor for Wnt proteins and norrin (NDP). In retina, it can be both activated by Wnt protein-binding, but also by a Wnt-independent signaling via binding of norrin (NDP), promoting in both cases beta-catenin (CTNNB1) accumulation and stimulation of LEF/TCF-mediated transcriptional programs. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues.
- Gene Name
- FZD4
Antibody
- Host Species
- Rabbit
- Clonality
- Polyclonal
- Isotype
- IgG
Immunogen
- Immunogen
- Recombinant Human Frizzled-4 protein (37-222AA)
- Immunogen Type
- Recombinant Immunogen
Format
- Conjugate/Label
- Unconjugated
- Format
- Liquid
- Formulation
- PBS, pH 7.4, 0.03% Proclin 300, 50% glycerol.
- Preservative
- Yes
- Purification Method
- Protein G Affinity
Storage & Handling
- Storage Conditions
- Short term: -20°C; Long term: -80°C; Avoid freeze-thaw cycles.
- Recommended Storage Buffer
- PBS