Immunohistochemistry of paraffin-embedded human placenta tissue using CRTC1 Antibody at dilution of 1:100
CRTC1 / MECT1 / TORC1 Antibody
Primary AntibodyLSBio Guarantee
| Antibody: | Rabbit Polyclonal |
| Applications: | Enzyme-Linked Immunosorbent Assay, Immunofluorescence, Immunohistochemistry (general) |
| Reactivity: | Human |
| Format: | Liquid |
$300.00each
Catalog Number: LS-C501162-50
Catalog Number: LS-C501162
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- Description
- TORC1 antibody LS-C501162 is an unconjugated rabbit polyclonal antibody to human TORC1 (CRTC1 / MECT1). Validated for ELISA, IF and IHC.
- Application
- ELISA, IF, IHC
- Reactivity
- Hu
- Intended Use
- Research Use Only
- Guarantees
- This antibody carries the LSBio 100% Guarantee. ✓
- Category
- Antibodies > Primary Antibodies > Polyclonal Antibodies
- Alternative Names
- CRTC1 | KIAA0616 | MECT1 | TORC-1 | TORC1 | Transducer of CREB protein 1 | WAMTP1
- UniProt Number
- Q6UUV9
- NCBI GenBank
- NM_001098482 | NP_001091952.1
- SwissProt
- Q6UUV9
Target
- Target
- Human CRTC1 / MECT1 / TORC1
- Antigen Species
- Human
- Epitope
- Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 'Ser-133' phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates the expression of specific CREB-activated genes such as the steroidogenic gene, StAR. Potent coactivator of PGC1alpha and inducer of mitochondrial biogenesis in muscle cells. Also coactivator for TAX activation of the human T-cell leukemia virus type 1 (HTLV-1) long terminal repeats (LTR). In the hippocampus, involved in late-phase long-term potentiation (L-LTP) maintenance at the Schaffer collateral-CA1 synapses. May be required for dendritic growth of developing cortical neurons (By similarity). In concert with SIK1, regulates the light-induced entrainment of the circadian clock. In response to light stimulus, coactivates the CREB-mediated transcription of PER1 which plays an important role in the photic entrainment of the circadian clock.
- Gene Name
- CRTC1
Antibody
- Host Species
- Rabbit
- Clonality
- Polyclonal
- Isotype
- IgG
Immunogen
- Immunogen
- Recombinant Human CREB-regulated transcription coactivator 1 protein (1-248AA)
- Immunogen Type
- Recombinant Immunogen
Format
- Conjugate/Label
- Unconjugated
- Format
- Liquid
- Formulation
- PBS, pH 7.4, 0.03% Proclin 300, 50% glycerol.
- Preservative
- Yes
- Purification Method
- Protein G Affinity
Storage & Handling
- Storage Conditions
- Short term: -20°C; Long term: -80°C; Avoid freeze-thaw cycles.
- Recommended Storage Buffer
- PBS