LSBio
Complement C3 Antibody (clone 10-21)

Complement C3 Antibody (clone 10-21)

Primary AntibodyLSBio Guarantee
Antibody:Mouse Monoclonal
Applications:Enzyme-Linked Immunosorbent Assay, Western Blot
Reactivity:Human
Format:Liquid
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$540.00each
Catalog Number: LS-C44973-0.1

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Overview

Description
Complement C3 antibody LS-C44973 is an unconjugated mouse monoclonal antibody to human Complement C3. Validated for ELISA and WB.
Application
ELISA, WB
Reactivity
Hu
Intended Use
Research Use Only
Guarantees
This antibody carries the LSBio 100% Guarantee. ✓
Category
Antibodies > Primary Antibodies > Monoclonal Antibodies
Alternative Names
AHUS5 | ARMD9 | C3 | Complement component C3 | CPAMD1 | Complement C3 | ASP | Complement component 3
Recommended Dilution: ELISA
1:1500 - 1:6000
UniProt Number
P01024
NCBI GenBank
NM_000064 | NP_000055.2
SwissProt
P01024

Target

Target
Human Complement C3
Antigen Species
Human
Epitope
Recognizes 9 kD complement component 3a (C3a) which is present in the blood serum. C3a is generated over the course of complement activation where complement 3 (C3) convertases cleave C3 to C3a and C3b, which is further degraded into iC3b and C3dg/C3d. C3 is crucial in the induction of tolerance generated when an antigen is introduced into immunoprivileged sites and this is exploited by pathogens and cancer cells to evade the immune system by inhibiting complement activation. C3a mediates local inflammatory process. It induces the contraction of smooth muscle, increases vascular permeability and causes histamine release from mast cells and basophilic leukocytes. C3a is expressed at significantly higher levels in colorectal cancer. Shows minimal reactivity with other complement proteins in radioimmunoassays and hemagglutination. Clone 10-21 has been reported to work in western blotting applications.
Gene Name
C3

Antibody

Host Species
Mouse
Clonality
Monoclonal
Clone
10-21
Isotype
IgG1

Immunogen

Immunogen
Native purified human C3a.
Immunogen Type
Native Protein (Purified from Natural Source)

Format

Conjugate/Label
Unconjugated
Format
Liquid
Formulation
BBS, 0.1% Sodium Azide
Volume
0.1 Milliliter
Preservative
Yes
Purification Method
Protein A Affinity

Storage & Handling

Storage Conditions
Store at 4°C or at -20°C. Store undiluted. Avoid freeze-thaw cycles. Microcentrifugation recommended if solution contains precipitate.
Recommended Storage Buffer
bbs

Request SDS/MSDS

To request an SDS/MSDS form for this product, please contact our Technical Support department at: technical@vectorlabs.com.