Immunohistochemistry analysis of paraffin-embedded human breast carcinoma, using Chk1 (Phospho-Ser345) Antibody. The picture on the right is blocked with the phospho peptide.
CHEK1 / CHK1 Antibody (phospho-Ser345)
Primary AntibodyLSBio Guarantee
| Antibody: | Rabbit Polyclonal |
| Applications: | Enzyme-Linked Immunosorbent Assay, Immunohistochemistry (general), Immunohistochemistry, Paraffin, Western Blot |
| Reactivity: | Human, Mouse, Rat |
| Format: | Liquid |
$341.00each
Catalog Number: LS-C117319-50
Catalog Number: LS-C117319
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- Description
- CHK1 antibody LS-C117319 is an unconjugated rabbit polyclonal antibody to CHK1 (CHEK1) (pSer345) from human. It is reactive with human, mouse and rat. Validated for IHC and Peptide-ELISA. Cited in 1 publication.
- Application
- ELISA, IHC, IHC-P, WB
- Reactivity
- Hu, Ms, Rt
- Intended Use
- Research Use Only
- Guarantees
- This antibody carries the LSBio 100% Guarantee. ✓
- Category
- Antibodies > Primary Antibodies > Polyclonal Antibodies
- Alternative Names
- CHEK1 | CHK1 checkpoint homolog | Cell cycle checkpoint kinase | Checkpoint kinase 1 | CHK1 | Chk1-S | Protein kinase chk1 | Checkpoint kinase-1
- UniProt Number
- O14757
- NCBI GenBank
- NM_001274 | NP_001265.2
- SwissProt
- O14757
Target
- Target
- Human CHEK1 / CHK1
- Antigen Species
- Human
- Epitope
- Chk1 (Phospho-Ser345) Antibody detects endogenous levels of Chk1 only when phosphorylated at serine345.
- Gene Name
- CHEK1
Antibody
- Host Species
- Rabbit
- Clonality
- Polyclonal
- Isotype
- IgG
Immunogen
- Immunogen
- Synthetic peptide from human Chk1 around the phosphorylation site of Ser345. (AA Range: 310-359)
- Immunogen Type
- Synthetic Peptide (Linear)
Format
- Conjugate/Label
- Unconjugated
- Format
- Liquid
- Formulation
- PBS (without Mg2+, Ca2+), pH 7.4, 150 mM NaCl, 0.02% Sodium Azide, 50% Glycerol
- Concentration
- 1 mg/mL
- Volume
- 50 Microliter
- Preservative
- Yes
- Purification Method
- Affinity Purified
Storage & Handling
- Storage Conditions
- Store at -20°C for up to 1 year.
- Recommended Storage Buffer
- PBS|150 mM NaCl
Evaluation of CHK1 activation in vulvar squamous cell carcinoma and its potential as a therapeutic target in vitro. Wang Z, Førsund MS, Trope CG, Nesland JM, Holm R, Slipicevic A. Cancer medicine. 2018 August;7:3955-3964. PubMed: 29963769 PMC: PMC6089182