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| Catalog Number | Size | Price |
|---|---|---|
| LS-A374-50 | 50 µg (0.6 mg/ml) | $440 |
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PathPlus™ Polyclonal Rabbit anti‑Human UTS2R / GPR14 Antibody (Cytoplasmic Domain, IHC) LS‑A374
PathPlus™ Polyclonal Rabbit anti‑Human UTS2R / GPR14 Antibody (Cytoplasmic Domain, IHC) LS‑A374
Antibody:
UTS2R / GPR14 Rabbit anti-Human Polyclonal (Cytoplasmic Domain) Antibody
Application:
IHC, IHC-P
Reactivity:
Human
Format:
Unconjugated, Unmodified
Overview
Antibody:
UTS2R / GPR14 Rabbit anti-Human Polyclonal (Cytoplasmic Domain) Antibody
Application:
IHC, IHC-P
Reactivity:
Human
Format:
Unconjugated, Unmodified
Specifications
Description
UTS2R is a high affinity receptor for urotensin-2 and urotensin-2B. The activity of this receptor is mediated by a G-protein that activate a phosphatidylinositol-calcium second messenger system. Functionally, UTS2R is involved in regulating autophagy and plays a role in chemotactic migration. Binding of UTS2 to UTS2R may stimulate the migration of neoplastic cells of various cancers including colorectal cancer, prostate cancer, and glioma. In immunohistochemistry, UTS2R has membranous positivity in the thyroid gland, the cerebral cortex in the brain, the testes, heart and skeletal muscle, and low levels of expression in the gastrointestinal tract and a few other tissues throughout the body.
References: Autophagy. 2016; 12(12): 2344–2362, PMID: 27715446
Target
Human UTS2R / GPR14
Synonyms
UTS2R | G protein-coupled receptor 14 | GPR14 | G-protein coupled receptor 14 | UII-receptor | Urotensin 2 receptor | UT-II | UTR | UTR2 | Uii-r | UR-2-R | Senr | Uii-r1a | Uiir | UR-II-R | Urotensin II receptor | Urotensin-2 receptor
Host
Rabbit
Reactivity
Human
(tested or 100% immunogen sequence identity)
Clonality
Polyclonal
Conjugations
Unconjugated
Purification
Immunoaffinity purified
Modifications
Unmodified
Immunogen
Synthetic 20 amino acid peptide from 1st cytoplasmic domain of human UTS2R / GPR14. Percent identity with other species by BLAST analysis:
Epitope
Cytoplasmic Domain
Specificity
Human UTS2R / GPR14. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
Applications
- IHC
- IHC - Paraffin (7 - 13 µg/ml)
|
Performing IHC? See our complete line of Immunohistochemistry Reagents including antigen retrieval solutions, blocking agents
ABC Detection Kits and polymers, biotinylated secondary antibodies, substrates and more.
|
Presentation
PBS, 0.1% Sodium Azide
Storage
Aliquot and store undiluted at -20°C or below for up to 1 year. Can be stored undiluted at 4°C for up to 1 month. Avoid freeze-thaw cycles.
Restrictions
For research use only. Intended for use by laboratory professionals.
About UTS2R / GPR14
Validation
Skin, Malignant Melanoma
Skin, Malignant Melanoma
Lung, non small-cell carcinoma
Lung, non small-cell carcinoma
Breast, Carcinoma
Breast, Carcinoma
Human, Brain, Cortex: Formalin-Fixed, Paraffin-Embedded (FFPE)
Human, Brain, Cortex: Formalin-Fixed, Paraffin-Embedded (FFPE)
See More About...
LSBio Ratings
PathPlus™ UTS2R / GPR14 Antibody (Cytoplasmic Domain) for IHC LS-A374 has an LSBio Rating of
Laboratory Validation Score (5)
Learn more about The LSBio Ratings Algorithm
Publications (0)
Customer Reviews (0)
Featured Products
Species:
Human, Monkey
Applications:
IHC, IHC - Paraffin
Species:
Human, Monkey
Applications:
IHC, IHC - Paraffin
Reactivity:
Mouse
Range:
2.47-200 ng/ml
Request SDS/MSDS
To request an SDS/MSDS form for this product, please contact our Technical Support department at:
Technical.Support@LSBio.com
Requested From: United States
Date Requested: 4/18/2024
Date Requested: 4/18/2024
