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Anti-Complement C8 Antibody (clone 056B-373) LS-C44994

Note: This antibody replaces LS-C123310

Ordering

Wt. Vol. Conc. Price
100 µg - 1 mg/ml $405
Inquire for larger quantities

LSBio (Direct) LSBio (Direct)
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Mouse Monoclonal [clone 056B-373] (IgG1) to Human Complement C8
Human
IHC - Frozen, Western blot, Flow Cytometry, ELISA
Unconjugated

Details

Human Complement C8
Mouse
Human (tested or 100% immunogen sequence identity)
IgG1 Monoclonal [056B-373]
Unconjugated
Protein A purified
Unmodified

Applications

  • IHC - Frozen
  • Western blot
  • Flow Cytometry
  • ELISA

Specificity and Use

Complement C8 antibody was raised against purified human C8.
Recognizes complement component 8 (C8), a 151 kD member of the complement C6/C7/C8/C9 family, present in blood serum. C8 is a terminal component of the complement system, part of both the complement membrane attack complex (MAC), and important to MAC assembly. C8 binds to the C5b-7 complex, anchored to the membrane, creating C5b-8. C5b-8 binds C9 and catalyses the polymerization of C9 molecules to form C5-b9 (MAC). C8 is thought to contain lipid binding sites, facilitating the insertion of MAC into the membrane. Defects in the alpha chain of C8 can result in complement C8 deficiency type I. Furthermore, C8 deficiencies can cause recurring bacterial infections, in particular from Neisseria meningitides.

Packaging

Borate buffered saline, pH 8.2 - 8.4, 0.02% sodium azide.
+4°C or -20°C, Avoid repeated freezing and thawing.
For research use only.

About Complement C8

Complement component 8 is a protein involved in the complement system. A hereditary deficiency of C8 can result in increased susceptibility to Neisseria infections, such as meningitis and gonorrhea.

Requested From: United States
Date Requested: 12/5/2016

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