Formalin-fixed, paraffin-embedded human Lymphoma stained with CD8a Rabbit Recombinant Monoclonal Antibody (C8/1779R).
CD8A / CD8 Alpha Antibody (clone C8/1779R)
Primary AntibodyLSBio Guarantee
| Antibody: | Rabbit Recombinant Monoclonal |
| Applications: | Immunohistochemistry, Paraffin |
| Reactivity: | Human |
| Format: | Liquid |
$379.00each
Catalog Number: LS-C751440-20
Catalog Number: LS-C751440
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- Description
- CD8 Alpha antibody LS-C751440 is an unconjugated rabbit recombinant monoclonal antibody to human CD8 Alpha (CD8A). Validated for IHC.
- Application
- IHC-P
- Reactivity
- Hu
- Intended Use
- Research Use Only
- Guarantees
- This antibody carries the LSBio 100% Guarantee. ✓
- Category
- Antibodies > Primary Antibodies > Recombinant Antibodies
- Alternative Names
- CD8a molecule | CD8a antigen | CD8A | OKT8 T-cell antigen | Leu2 T-lymphocyte antigen | T8 T-cell antigen | T cell co-receptor | p32 | CD8 | Leu2 | T-cell antigen Leu2
- Recommended Dilution: IHC-P
- 0.5 - 1 µg/ml
- UniProt Number
- P01732
- NCBI GenBank
- NM_001768 | NP_001759.3
- SwissProt
- P01732
Target
- Target
- Human CD8A / CD8 Alpha
- Antigen Species
- Human
- Epitope
- CD8 is a cell surface receptor expressed either as a heterodimer with the CD8 beta chain (CD8 alpha/beta) or as a homodimer (CD8 alpha/alpha). A majority of thymocytes and a subpopulation of mature T cells and NK cells express CD8a. CD8 binds to MHC class 1 and through its association with protein tyrosine kinase p56lck plays a role in T cell development and activation of mature T cells. For mature T-cells, CD4 and CD8 are mutually exclusive, so anti-CD8, generally used in conjunction with anti-CD4. It is a useful marker for distinguishing helper/inducer T-lymphocytes, and most peripheral T-cell lymphomas are CD4+/CD8-. Anaplastic large cell lymphoma is usually CD4+ and CD8-, and in T-lymphoblastic lymphoma/leukemia, CD4 and CD8 are often co-expressed. CD8 is also found in littoral cell angioma of the spleen.
- Gene Name
- CD8A
Antibody
- Host Species
- Rabbit
- Clonality
- Recombinant Monoclonal
- Clone
- C8/1779R
- Isotype
- IgG
- Origin Species
- Human
Immunogen
- Immunogen
- Recombinant full-length human CD8a protein. Antigen Molecular Weight: 32 kDa
- Immunogen Type
- Recombinant Immunogen
Format
- Conjugate/Label
- Unconjugated
- Format
- Liquid
- Formulation
- 10 mM PBS, 0.05% BSA, 0.05% Sodium Azide
- Concentration
- 200 µg/mL
- Preservative
- Yes
- Purification Method
- Protein A Affinity
Storage & Handling
- Storage Conditions
- Store at 2°C to 8°C for up to 2 years.
- Recommended Storage Buffer
- 10 mM PBS