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Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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AHR Antibody (N‑Terminus) IHC‑plus™ LS‑A3005
Note: This antibody replaces LS-C63830, LS-C42630
AHR antibody LS-A3005 is an unconjugated rabbit polyclonal antibody to human AHR. Validated for IHC. Tested on 20 paraffin-embedded human tissues.
Catalog
Size
Price
LS-A3005-50
50 µg (1 mg/ml)
Unavailable
In Stock for Immediate Shipment

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Antibody
Species: Human, Mouse
Applications: IHC, ICC, Immunofluorescence, Western blot, Flow Cytometry, ELISA

Product Description

AHR antibody LS-A3005 is an unconjugated rabbit polyclonal antibody to human AHR. Validated for IHC. Tested on 20 paraffin-embedded human tissues.
About AHR
Ligand-activated transcriptional activator. Binds to the XRE promoter region of genes it activates. Activates the expression of multiple phase I and II xenobiotic chemical metabolizing enzyme genes (such as the CYP1A1 gene). Mediates biochemical and toxic effects of halogenated aromatic hydrocarbons. Involved in cell-cycle regulation. Likely to play an important role in the development and maturation of many tissues. P35869 NM_001621 NP_001612.1

AHR Antibody, Ah receptor Antibody, AH-receptor Antibody, Aryl hydrocarbon receptor Antibody, BHLHe76 Antibody, Aromatic hydrocarbon receptor Antibody


Specifications

Target
Human AHR
Host
Rabbit
Reactivity
Human (tested or 100% immunogen sequence identity)
Predicted
Monkey, Horse (at least 90% immunogen sequence identity)
Clonality
Polyclonal
Conjugations
Unconjugated. Also available conjugated with AP, APC, Biotin, FITC, HRP, PE.
Purification
Immunoaffinity purified
Modifications
Unmodified
Applications
  • IHC
  • IHC - Paraffin (6 µg/ml)
  • (applications tested for the base form of this product only)
Performing IHC? See our complete line of Immunohistochemistry Reagents including antigen retrieval solutions, blocking agents ABC Detection Kits and polymers, biotinylated secondary antibodies, substrates and more.
Immunogen
AHR antibody was raised against synthetic 16 amino acid peptide from N-terminus of human Aryl Hydrocarbon Receptor. Percent identity with other species by BLAST analysis: Human, Gorilla (100%); Gibbon, Monkey, Horse (94%); Marmoset, Bovine (88%); Bat, Dog, Hamster, Panda, Guinea pig (81%).
Blocking Peptide
LS-E28669 - Liquid - 50 µg - $145.00
Immunizing peptide used to generate LS-A3005. Useful for pre-absorption and neutralization of the antibody's antigen binding site.
Epitope
N-Terminus
Specificity
Human Aryl Hydrocarbon Receptor. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
Usage
Immunohistochemistry: LS-A3005 was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary antibody, slides were incubated with biotinylated secondary antibody, followed by alkaline phosphatase-streptavidin and chromogen. The stained slides were evaluated by a pathologist to confirm staining specificity. The optimal working concentration for LS-A3005 was determined to be 6 ug/ml.
Presentation
PBS, less than 0.1% sodium azide.
Storage
Aliquot and store undiluted at -20°C or below for up to 1 year. Can be stored undiluted at 4°C for up to 1 month. Avoid freeze-thaw cycles.
Restrictions
For research use only.
Guarantee
This antibody carries the LSBio 100% Guarantee.

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Images


Immunohistochemistry

Anti-Aryl Hydrocarbon Receptor antibody LS-A3005 IHC of human respiratory epithelium and bronchial smooth muscle. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-Aryl Hydrocarbon Receptor antibody LS-A3005 IHC of human respiratory epithelium and bronchial smooth muscle. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

Immunohistochemistry

Anti-Aryl Hydrocarbon Receptor antibody LS-A3005 IHC of human respiratory epithelium and bronchial smooth muscle. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-Aryl Hydrocarbon Receptor antibody LS-A3005 IHC of human respiratory epithelium and bronchial smooth muscle. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

Immunohistochemistry

Anti-Aryl Hydrocarbon Receptor antibody LS-A3005 IHC of human respiratory epithelium and bronchial smooth muscle. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-Aryl Hydrocarbon Receptor antibody LS-A3005 IHC of human respiratory epithelium and bronchial smooth muscle. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

Immunohistochemistry

Anti-Aryl Hydrocarbon Receptor antibody LS-A3005 IHC of human respiratory epithelium and bronchial smooth muscle. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-Aryl Hydrocarbon Receptor antibody LS-A3005 IHC of human respiratory epithelium and bronchial smooth muscle. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.


Requested From: 
Date Requested: 6/19/2018

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