Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
(applications tested for the base form of this product only)
Performing IHC? See our complete line of Immunohistochemistry Reagents including antigen retrieval solutions, blocking agents
ABC Detection Kits and polymers, biotinylated secondary antibodies, substrates and more.
ACVR1C / ALK7 antibody was raised against synthetic 16 amino acid peptide from internal region of human ACVR1C. Percent identity with other species by BLAST analysis: Human, Gorilla, Gibbon, Monkey, Bovine, Bat, Pig (100%); Marmoset, Elephant, Panda, Horse, Rabbit (94%); Opossum, Turkey, Chicken, Platypus (88%).
LS-E29214 - Liquid - 50 µg - $145.00
Immunizing peptide used to generate LS-A7018. Useful for pre-absorption and neutralization of the antibody's antigen binding site.
Human ACVR1C. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
Immunohistochemistry with formalin-fixed paraffin-embedded tissues requires pretreatment with Proteinase K.
PBS, 0.1% Sodium Azide
Aliquot and store undiluted at -20°C or below for up to 1 year. Can be stored undiluted at 4°C for up to 1 month. Avoid freeze-thaw cycles.
ALK7, a Activin/TGFb type protein kinase, is a member of the Nodal signaling pathway, which is implicated in developmental events such as mesoderm formation and left-right axis specification. ALK7 is a type I receptor that has been shown to collaborate with activin receptor type 2B (ActRIIB). A constitutively active form of ALK7 has been shown to increase phosphorylation of Smad2, a receptor-regulated signaling protein which translocate to the nucleus to activate transcription.