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Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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ACVR1C / ALK7 Antibody (Internal) IHC‑plus™ LS‑A7018
ALK7 antibody LS-A7018 is an unconjugated rabbit polyclonal antibody to ALK7 (ACVR1C) from human, bat, bovine and other species. Validated for IHC. Tested on 20 paraffin-embedded human tissues.
Catalog
Size
Price
LS-A7018-50
50 µg (1 mg/ml)
$425
In Stock for Immediate Shipment

Popular ACVR1C / ALK7 Products

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Product Description

ALK7 antibody LS-A7018 is an unconjugated rabbit polyclonal antibody to ALK7 (ACVR1C) from human, bat, bovine and other species. Validated for IHC. Tested on 20 paraffin-embedded human tissues.
About ACVR1C / ALK7
ALK7, a Activin/TGFb type protein kinase, is a member of the Nodal signaling pathway, which is implicated in developmental events such as mesoderm formation and left-right axis specification. ALK7 is a type I receptor that has been shown to collaborate with activin receptor type 2B (ActRIIB). A constitutively active form of ALK7 has been shown to increase phosphorylation of Smad2, a receptor-regulated signaling protein which translocate to the nucleus to activate transcription. Q8NER5 NM_145259 NP_660302.2

ACVR1C Antibody, Activin receptor-like kinase 7 Antibody, ACTR-IC Antibody, Activin receptor type IC Antibody, ACVRLK7 Antibody, Activin receptor type-1C Antibody, ALK7 Antibody, Activin A receptor, type IC Antibody, ALK-7 Antibody


Specifications

Target
Human ACVR1C / ALK7
Host
Rabbit
Reactivity
Human, Bat, Bovine, Pig (tested or 100% immunogen sequence identity)
Predicted
Monkey, Horse, Rabbit (at least 90% immunogen sequence identity)
Clonality
Polyclonal
Conjugations
Unconjugated. Also available conjugated with AP, APC, Biotin, FITC, HRP, PE.
Purification
Immunoaffinity purified
Modifications
Unmodified
Applications
  • IHC
  • IHC - Paraffin (5 µg/ml)
  • (applications tested for the base form of this product only)
Performing IHC? See our complete line of Immunohistochemistry Reagents including antigen retrieval solutions, blocking agents ABC Detection Kits and polymers, biotinylated secondary antibodies, substrates and more.
Immunogen
ACVR1C / ALK7 antibody was raised against synthetic 16 amino acid peptide from internal region of human ACVR1C. Percent identity with other species by BLAST analysis: Human, Gorilla, Gibbon, Monkey, Bovine, Bat, Pig (100%); Marmoset, Elephant, Panda, Horse, Rabbit (94%); Opossum, Turkey, Chicken, Platypus (88%).
Blocking Peptide
LS-E29214 - Liquid - 50 µg - $145.00
Immunizing peptide used to generate LS-A7018. Useful for pre-absorption and neutralization of the antibody's antigen binding site.
Epitope
Internal
Specificity
Human ACVR1C. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
Usage
Immunohistochemistry with formalin-fixed paraffin-embedded tissues requires pretreatment with Proteinase K.
Presentation
PBS, 0.1% Sodium Azide
Storage
Aliquot and store undiluted at -20°C or below for up to 1 year. Can be stored undiluted at 4°C for up to 1 month. Avoid freeze-thaw cycles.
Restrictions
For research use only.

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Images

Immunohistochemistry

Anti-ACVR1C antibody LS-A7018 IHC of human colon. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-ACVR1C antibody LS-A7018 IHC of human colon. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

Immunohistochemistry

Anti-ACVR1C antibody LS-A7018 IHC of human spleen. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-ACVR1C antibody LS-A7018 IHC of human spleen. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

Immunohistochemistry

Anti-ACVR1C antibody LS-A7018 IHC of human colon. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-ACVR1C antibody LS-A7018 IHC of human colon. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

Immunohistochemistry

Anti-ACVR1C antibody LS-A7018 IHC of human spleen. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-ACVR1C antibody LS-A7018 IHC of human spleen. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

Immunohistochemistry

Anti-ACVR1C antibody LS-A7018 IHC of human colon. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-ACVR1C antibody LS-A7018 IHC of human colon. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

Immunohistochemistry

Anti-ACVR1C antibody LS-A7018 IHC of human spleen. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-ACVR1C antibody LS-A7018 IHC of human spleen. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

Immunohistochemistry

Anti-ACVR1C antibody LS-A7018 IHC of human colon. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-ACVR1C antibody LS-A7018 IHC of human colon. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

Immunohistochemistry

Anti-ACVR1C antibody LS-A7018 IHC of human spleen. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-ACVR1C antibody LS-A7018 IHC of human spleen. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

Requested From: United States
Date Requested: 9/20/2018

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