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Anti-ACKR3 / CXCR7 Antibody (Cytoplasmic Domain) IHC-plus™ LS-A1439

Catalog Size Price
LS-A1439-50 50 µg (1 mg/ml) Unavailable
Same day shipping In Stock - Same day shipping

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100% Guaranteed In Stock Publications (1)
Rabbit Polyclonal to Human ACKR3 / CXCR7
Human, Horse
IHC - Paraffin, Western blot
Unconjugated

Details

Human ACKR3 / CXCR7
Rabbit
Human, Horse (tested or 100% immunogen sequence identity)
Monkey, Dog (at least 90% immunogen sequence identity)
Polyclonal
Unconjugated
Immunoaffinity purified
Unmodified

Applications

  • IHC - Paraffin (4 µg/ml)
  • Western blot

Specificity and Use

ACKR3 / CXCR7 antibody was raised against synthetic 17 amino acid peptide from 3rd cytoplasmic domain of human CXCR7. Percent identity with other species by BLAST analysis: Human, Horse (100%); Gorilla, Gibbon, Monkey, Marmoset, Dog, Elephant (94%); Mouse, Rat, Hamster (88%); Bat, Bovine, Rabbit, Pig, Opossum (82%).
LS-E28279 - Liquid - 50 µg - $145.00
Immunizing peptide used to generate LS-A1439. Useful for pre-absorption and neutralization of the antibody's antigen binding site.
Cytoplasmic Domain
Human CXCR7. BLAST analysis of the peptide immunogen showed no homology with other human proteins.

Packaging

PBS, less than 0.1% sodium azide.
Aliquot and store undiluted at -20°C or below for up to 1 year. Can be stored undiluted at 4°C for up to 1 month. Avoid freeze thaw cycles.
For research use only.

Publications (1)

1
The IL-8-regulated chemokine receptor CXCR7 stimulates EGFR signaling to promote prostate cancer growth. Singh RK, Lokeshwar BL. Cancer research. 2011 May;71:3268-77. [Full Text Article] [PubMed:21398406] [PMC:PMC3085571]

About ACKR3 / CXCR7

P25106 NM_020311 NP_064707.1

ACKR3 Antibody, Chemokine orphan receptor 1 Antibody, CMKOR1 Antibody, CXCR7 Antibody, CXC-R7 Antibody, GPRN1 Antibody, RDC1 Antibody, RDC-1 Antibody, CXCR-7 Antibody, G-protein coupled receptor 159 Antibody, GPR159 Antibody

Atypical chemokine receptor that controls chemokine levels and localization via high-affinity chemokine binding that is uncoupled from classic ligand-driven signal transduction cascades, resulting instead in chemokine sequestration, degradation, or transcytosis. Also known as interceptor (internalizing receptor) or chemokine-scavenging receptor or chemokine decoy receptor. Acts as a receptor for chemokines CXCL11 and CXCL12/SDF1.

Immunohistochemistry

Immunohistochemistry
Anti-ACKR3 / CXCR7 / RDC1 antibody IHC of human Colon, Carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

Immunohistochemistry

Immunohistochemistry
Anti-CXCR7 antibody LS-A1439 IHC of human kidney, renal tubules. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

Requested From: 
Date Requested: 8/22/2017

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