LSBio The Immunohistochemistry Antibody Company
  • Home
  • Antibodies
    • Primary Antibodies
    • Secondary Antibodies
    • IHC-plus Antibodies
    • Isotype Control Antibodies
    • Blocking Peptides
  • ELISA Kits
    • All Kits
    • Sandwich ELISA Kits
    • EIA Kits
    • Cell-Based ELISA Kits
    • DNA-Binding ELISA Kits
  • Services
    • Immunohistochemistry Studies
    • Tissue Cross-Reactivity Screening
  • Distributors
  • Resources
    • About our Tissue Bank
    • Customer Support
    • How to Buy
    • IHC-plus Protocol
    • LSBio Media
    • Publications
    • Antibody Reports
  • Company
    • About LifeSpan
    • Press Releases
    • Holiday Schedule
    • Contact Us
  • View Cart

Unfortunately, the antibody LS-C284340 is no longer available.

Below is a list of antibodies to the same protein target. You may also try your search again using the search box at the top of the page. Please contact us if you have any questions.



WRN Antibodies

Werner syndrome, RecQ helicase-like

Gene Name: Werner syndrome, RecQ helicase-like
Synonyms: WRN Antibody, Exonuclease WRN Antibody, RecQ protein-like 2 Antibody, RECQL2 Antibody, RECQL3 Antibody, Werner syndrome Antibody, RECQ3 Antibody, DNA helicase, RecQ-like type 3 Antibody
Target Sequences: NM_000553 NP_000544.2 Q14191
 WRN Feature Table

WRN Antibodies (20)

Target Reactivity Applications Host Isotype Clonality Clone Format Epitope Publications Type
WRN Rabbit IgG Polyclonal Unconjugated Human, Chimpanzee, Orangutan IHC-P, IF C-Terminus No Primary
Anti-WRN Antibody (C-Terminus) LS-C286637
IHC Image
Rabbit Polyclonal (IgG) to Human WRN
Human, Chimpanzee, Orangutan
IHC - Paraffin, Immunofluorescence
Unconjugated
WRN Mouse IgG1 Monoclonal Unconjugated Human, Mouse IHC, ICC, WB, IP No Primary
Anti-WRN Antibody LS-C144273
Mouse Monoclonal (IgG1) to Human WRN
Human, Mouse
IHC, ICC, Western blot, Immunoprecipitation
Unconjugated
WRN Rabbit IgG Monoclonal EPR6391 Unconjugated Human WB, IP, Flo Internal No Primary
Anti-WRN Antibody (Internal, clone EPR6391) LS-C152499
Flo Image
WB Image
Rabbit Monoclonal [clone EPR6391] (IgG) to Human WRN
Human
Western blot, Immunoprecipitation, Flow Cytometry
Unconjugated
WRN Rabbit Polyclonal Unconjugated Human WB, Flo aa794-825 No Primary
Anti-WRN Antibody (aa794-825) LS-C160640
Flo Image
WB Image
Rabbit Polyclonal to Human WRN
Human
Western blot, Flow Cytometry
Unconjugated
WRN Rabbit Monoclonal EPR6392 Unconjugated Human ICC, WB C-Terminus No Primary
Anti-WRN Antibody (C-Terminus, clone EPR6392) LS-C138791
WB Image
Rabbit Monoclonal [clone EPR6392] to Human WRN
Human
ICC, Western blot
Unconjugated
WRN Rabbit Polyclonal Unconjugated Human WB, IP aa1400-1432 No Primary
Anti-WRN Antibody (aa1400-1432) LS-C56972
WB Image
Rabbit Polyclonal to Human WRN
Human
Western blot, Immunoprecipitation
Unconjugated
WRN Mouse IgG1,k Monoclonal 2F7 Unconjugated Human WB, ELISA No Primary
Anti-WRN Antibody (clone 2F7) LS-C198442
WB Image
Mouse Monoclonal [clone 2F7] (IgG1,k) to Human WRN
Human
Western blot, ELISA
Unconjugated
WRN Rabbit IgG Polyclonal Unconjugated Human WB, ELISA pSer1141 No Primary
Anti-WRN Antibody (phospho-Ser1141) LS-C199734
WB Image
Rabbit Polyclonal (IgG) to Human WRN
Human
Western blot, ELISA
Unconjugated
WRN Rabbit IgG Polyclonal Unconjugated Human, Chimpanzee, Orangutan WB, IP C-Terminus No Primary
Anti-WRN Antibody (C-Terminus) LS-C287156
Rabbit Polyclonal (IgG) to Human WRN
Human, Chimpanzee, Orangutan
Western blot, Immunoprecipitation
Unconjugated
WRN Rabbit IgG Polyclonal Unconjugated Human WB, IP aa400-450 No Primary
Anti-WRN Antibody (aa400-450) LS-C287155
Rabbit Polyclonal (IgG) to Human WRN
Human
Western blot, Immunoprecipitation
Unconjugated
WRN Rabbit IgG Polyclonal Biotin Conjugated Human WB, Flo, ELISA aa794-825 No Primary
Anti-WRN Antibody (aa794-825, Biotin) LS-C273640
Rabbit Polyclonal (IgG) to Human WRN
Human
Western blot, Flow Cytometry, ELISA
Biotin Conjugated
WRN Rabbit IgG Polyclonal FITC Conjugated Human WB, Flo, ELISA aa794-825 No Primary
Anti-WRN Antibody (aa794-825, FITC) LS-C273639
Rabbit Polyclonal (IgG) to Human WRN
Human
Western blot, Flow Cytometry, ELISA
FITC Conjugated
WRN Rabbit IgG Polyclonal PE Conjugated Human WB, Flo, ELISA aa794-825 No Primary
Anti-WRN Antibody (aa794-825, PE) LS-C273642
Rabbit Polyclonal (IgG) to Human WRN
Human
Western blot, Flow Cytometry, ELISA
PE Conjugated
WRN Rabbit IgG Polyclonal HRP Conjugated, Azide-free Human WB, Flo, ELISA aa794-825 No Primary
Anti-WRN Antibody (aa794-825, Azide-free, HRP) LS-C273641
Rabbit Polyclonal (IgG) to Human WRN
Human
Western blot, Flow Cytometry, ELISA
HRP Conjugated, Azide-free
WRN Mouse IgG2a Monoclonal Unconjugated, Azide-free Human IF, WB, ELISA aa1322-1433 No
Anti-WRN Antibody (aa1322-1433, Azide-free) LS-C329118
Mouse Monoclonal (IgG2a) to Human WRN
Human
Immunofluorescence, Western blot, ELISA
Unconjugated, Azide-free
WRN Rabbit IgG Polyclonal Unconjugated Human WB, Flo, ELISA aa794-825 No
Anti-WRN Antibody (aa794-825) LS-C326375
Rabbit Polyclonal (IgG) to Human WRN
Human
Western blot, Flow Cytometry, ELISA
Unconjugated
WRN Rabbit IgG Polyclonal APC Conjugated Human WB, Flo, ELISA aa794-825 No Primary
Anti-WRN Antibody (aa794-825, APC) LS-C273638
Rabbit Polyclonal (IgG) to Human WRN
Human
Western blot, Flow Cytometry, ELISA
APC Conjugated
WRN Rabbit IgG Polyclonal AP Conjugated Human WB, Flo, ELISA aa794-825 No Primary
Anti-WRN Antibody (aa794-825, AP) LS-C273637
Rabbit Polyclonal (IgG) to Human WRN
Human
Western blot, Flow Cytometry, ELISA
AP Conjugated
WRN Rabbit Polyclonal Unconjugated Human WB, IP C-Terminus No Primary
Anti-WRN Antibody (C-Terminus) LS-C90729
Rabbit Polyclonal to Human WRN
Human
Western blot, Immunoprecipitation
Unconjugated
WRN Rabbit Polyclonal Unconjugated Human WB, IP aa400-450 No Primary
Anti-WRN Antibody (aa400-450) LS-C90728
Rabbit Polyclonal to Human WRN
Human
Western blot, Immunoprecipitation
Unconjugated

WRN Feature Table


Feature Type Location Details
catalytic activity 1 - 1432 ATP + H(2)O = ADP + phosphate.
Disease 1 - 1432 Defects in WRN are a cause of Werner syndrome (WRN) [MIM:277700]. WRN is a rare autosomal recessive progeroid syndrome characterized by the premature onset of multiple age-related disorders, including atherosclerosis, cancer, non-insulin- dependent diabetes mellitus, ocular cataracts and osteoporosis. The major cause of death, at a median age of 47, is myocardial infarction. Currently all known WS mutations produces prematurely terminated proteins.
Disease 1 - 1432 Defects in WRN may be a cause of colorectal cancer (CRC) [MIM:114500].
Function 1 - 1432 Essential for the formation of DNA replication focal centers; stably associates with foci elements generating binding sites for RP-A. Exhibits a magnesium-dependent ATP-dependent DNA- helicase activity. May be involved in the control of genomic stability (By similarity).
interaction 1 - 1432 P54132:BLM; NbExp=4; IntAct=EBI-368417, EBI-621372; P39748:FEN1; NbExp=7; IntAct=EBI-368417, EBI-707816; P09874:PARP1; NbExp=2; IntAct=EBI-368417, EBI-355676; P43351:RAD52; NbExp=4; IntAct=EBI-368417, EBI-706448; P27694:RPA1; NbExp=4; IntAct=EBI-368417, EBI-621389; Q15554:TERF2; NbExp=4; IntAct=EBI-368417, EBI-706637; P04637:TP53; NbExp=2; IntAct=EBI-368417, EBI-366083; P55072:VCP; NbExp=1; IntAct=EBI-368417, EBI-355164; Q3ZBT1:VCP (xeno); NbExp=1; IntAct=EBI-368417, EBI-706432;
ptm 1 - 1432 Phosphorylated by PRKDC. Phosphorylated upon DNA damage, probably by ATM or ATR.
Similarity 1 - 1432 Belongs to the helicase family. RecQ subfamily.
Similarity 1 - 1432 Contains 1 3'-5' exonuclease domain.
Similarity 1 - 1432 Contains 1 helicase ATP-binding domain.
Similarity 1 - 1432 Contains 1 helicase C-terminal domain.
Similarity 1 - 1432 Contains 1 HRDC domain.
Subcellular Location 1 - 1432 Nucleus, nucleolus.
Subunit 1 - 1432 Interacts via its N-terminal domain with WRNIP1 (By similarity). Interacts with EXO1.
web resource 1 - 1432 Name=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http://atlasgeneticsoncology.org/Genes/WRNID284.html";
web resource 1 - 1432 Name=GeneReviews; URL="http://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/WRN";
web resource 1 - 1432 Name=NIEHS-SNPs; URL="http://egp.gs.washington.edu/data/wrn/";
web resource 1 - 1432 Name=WRN; Note=WRN mutation db (Warner disease); URL="http://www.pathology.washington.edu/werner/ws_wrn.html";
arrayexpress 1 - 1432 Q14191
bgee 1 - 1432 Q14191
cleanex 1 - 1432 HS_WRN
ctd 1 - 1432 7486
disprot 1 - 1432 DP00443
doi 1 - 1432 10
eggnog 1 - 1432 prNOG15288
embl 1 - 1432 AF091214
embl 1 - 1432 AF181896
embl 1 - 1432 AF181897
embl 1 - 1432 AY442327
embl 1 - 1432 AY818673
embl 1 - 1432 L76937
ensembl 1 - 1432 ENST00000298139
genecards 1 - 1432 GC08P030948
geneid 1 - 1432 7486
genevestigator 1 - 1432 Q14191
germonline 1 - 1432 ENSG00000165392
go 1 - 1432 GO:0000403
go 1 - 1432 GO:0000405
go 1 - 1432 GO:0000723
go 1 - 1432 GO:0000731
go 1 - 1432 GO:0005524
go 1 - 1432 GO:0005654
go 1 - 1432 GO:0005730
go 1 - 1432 GO:0005813
go 1 - 1432 GO:0006284
go 1 - 1432 GO:0006310
go 1 - 1432 GO:0006979
go 1 - 1432 GO:0008408
go 1 - 1432 GO:0009378
go 1 - 1432 GO:0010225
go 1 - 1432 GO:0010259
go 1 - 1432 GO:0031297
go 1 - 1432 GO:0032403
go 1 - 1432 GO:0042803
go 1 - 1432 GO:0042981
go 1 - 1432 GO:0043140
go 1 - 1432 GO:0051345
go 1 - 1432 GO:0051880
h-invdb 1 - 1432 HIX0007441
hgnc 1 - 1432 HGNC:12791
hogenom 1 - 1432 HBG447065
hovergen 1 - 1432 HBG000325
hpa 1 - 1432 HPA028661
inparanoid 1 - 1432 Q14191
intact 1 - 1432 Q14191
interpro 1 - 1432 IPR001650
interpro 1 - 1432 IPR002121
interpro 1 - 1432 IPR002562
interpro 1 - 1432 IPR004589
interpro 1 - 1432 IPR011545
interpro 1 - 1432 IPR012337
interpro 1 - 1432 IPR014001
interpro 1 - 1432 IPR014021
interpro 1 - 1432 IPR018329
interpro 1 - 1432 IPR018982
ipi 1 - 1432 IPI00029107
kegg 1 - 1432 hsa:7486
medline 1 - 1432 96181115
medline 1 - 1432 97173161
medline 1 - 1432 98111850
medline 1 - 1432 98284027
medline 1 - 1432 99160561
medline 1 - 1432 99167244
medline 1 - 1432 99235545
mim 1 - 1432 114500
mim 1 - 1432 277700
mim 1 - 1432 604611
mint 1 - 1432 MINT-95856
nextbio 1 - 1432 29326
orphanet 1 - 1432 902
panther 1 - 1432 PTHR13710
pathway_interaction_db 1 - 1432 telomerasepathway
pdb 1 - 1432 2AXL
pdb 1 - 1432 2DGZ
pdb 1 - 1432 2E1E
pdb 1 - 1432 2E1F
pdb 1 - 1432 2FBT
pdb 1 - 1432 2FBV
pdb 1 - 1432 2FBX
pdb 1 - 1432 2FBY
pdb 1 - 1432 2FC0
pdb 1 - 1432 3AAF
pdbsum 1 - 1432 2AXL
pdbsum 1 - 1432 2DGZ
pdbsum 1 - 1432 2E1E
pdbsum 1 - 1432 2E1F
pdbsum 1 - 1432 2FBT
pdbsum 1 - 1432 2FBV
pdbsum 1 - 1432 2FBX
pdbsum 1 - 1432 2FBY
pdbsum 1 - 1432 2FC0
pdbsum 1 - 1432 3AAF
pfam 1 - 1432 PF00270
pfam 1 - 1432 PF00271
pfam 1 - 1432 PF00570
pfam 1 - 1432 PF01612
pfam 1 - 1432 PF09382
pharmgkb 1 - 1432 PA367
phosphosite 1 - 1432 Q14191
phylomedb 1 - 1432 Q14191
pride 1 - 1432 Q14191
prosite 1 - 1432 PS00690
prosite 1 - 1432 PS50967
prosite 1 - 1432 PS51192
prosite 1 - 1432 PS51194
proteinmodelportal 1 - 1432 Q14191
pubmed 1 - 1432 10049920
pubmed 1 - 1432 10069711
pubmed 1 - 1432 10206685
pubmed 1 - 1432 10220139
pubmed 1 - 1432 11161804
pubmed 1 - 1432 11889123
pubmed 1 - 1432 12704184
pubmed 1 - 1432 16339893
pubmed 1 - 1432 16622405
pubmed 1 - 1432 16673358
pubmed 1 - 1432 16723399
pubmed 1 - 1432 16959974
pubmed 1 - 1432 17525332
pubmed 1 - 1432 18669648
pubmed 1 - 1432 18987736
pubmed 1 - 1432 19413330
pubmed 1 - 1432 19690332
pubmed 1 - 1432 8602509
pubmed 1 - 1432 9021029
pubmed 1 - 1432 9450180
pubmed 1 - 1432 9618508
refseq 1 - 1432 NP_000544.2
smart 1 - 1432 SM00341
smart 1 - 1432 SM00474
smart 1 - 1432 SM00487
smart 1 - 1432 SM00490
smr 1 - 1432 Q14191
string 1 - 1432 Q14191
supfam 1 - 1432 SSF53098
tigrfams 1 - 1432 TIGR00614
unigene 1 - 1432 Hs.632050
joined; genomic_dna 1 - 1432 AAF06162.1
chain 1 - 1432 Werner syndrome ATP-dependent helicase /FTId=PRO_0000205045.
compbias 507 - 510 Poly-Glu
domain 558 - 724 Helicase ATP-binding
domain 749 - 899 Helicase C-terminal
domain 1150 - 1229 HRDC
Modification 426 - 426 Phosphoserine
Modification 453 - 453 Phosphoserine
Modification 467 - 467 Phosphoserine
Modification 1058 - 1058 Phosphoserine
Modification 1133 - 1133 Phosphoserine
Modification 1141 - 1141 Phosphoserine
motif 668 - 671 DEAH box
np_bind 571 - 578 ATP (By similarity)
region 1 - 277 Interaction with WRNIP1 (By similarity)
region 424 - 477 2 X 27 AA tandem repeats of H-L-S-P-N-D- N-E-N-D-T-S-Y-V-I-E-S-D-E-D-L-E-M-E-M-L- K.
repeat 424 - 450 1
repeat 451 - 477 2
variant 32 - 32 K -> R (in dbSNP:rs34477820) /FTId=VAR_017453.
variant 92 - 92 G -> V (in a colorectal cancer sample; somatic mutation). /FTId=VAR_036318.
variant 114 - 114 V -> I (in dbSNP:rs2230009) /FTId=VAR_017454.
variant 125 - 125 K -> N (in WRN) /FTId=VAR_026588.
variant 135 - 135 K -> E (in WRN) /FTId=VAR_026589.
variant 172 - 172 T -> P /FTId=VAR_017455.
variant 240 - 240 N -> K /FTId=VAR_017456.
variant 324 - 324 T -> A (in dbSNP:rs1800390) /FTId=VAR_006904.
variant 329 - 329 Q -> R (in dbSNP:rs4987237) /FTId=VAR_020450.
variant 343 - 343 E -> K (in dbSNP:rs11574222) /FTId=VAR_018941.
variant 383 - 383 L -> F (in dbSNP:rs4987238) /FTId=VAR_020451.
variant 383 - 383 L -> W /FTId=VAR_017457.
variant 387 - 387 M -> I (in dbSNP:rs1800391) /FTId=VAR_006905.
variant 533 - 533 N -> S (in dbSNP:rs11574240) /FTId=VAR_018942.
variant 612 - 612 S -> C (in dbSNP:rs11574250) /FTId=VAR_018943.
variant 708 - 708 S -> F (in dbSNP:rs11574289) /FTId=VAR_018944.
variant 711 - 711 R -> W (in dbSNP:rs34560788) /FTId=VAR_057124.
variant 724 - 724 Q -> L /FTId=VAR_017458.
variant 834 - 834 R -> C (in dbSNP:rs3087425) /FTId=VAR_014913.
variant 912 - 912 I -> S (in dbSNP:rs11574323) /FTId=VAR_018945.
variant 1074 - 1074 F -> L (in dbSNP:rs1801195) /FTId=VAR_007903.
variant 1079 - 1079 S -> L (in dbSNP:rs3087414) /FTId=VAR_014914.
variant 1133 - 1133 S -> A (in dbSNP:rs11574358) /FTId=VAR_018946.
variant 1141 - 1141 S -> L /FTId=VAR_054162.
variant 1269 - 1269 K -> E /FTId=VAR_017459.
variant 1339 - 1339 V -> I (in dbSNP:rs11574395) /FTId=VAR_018947.
variant 1367 - 1367 C -> R (polymorphism associated with a higher risk of myocardial infarction; dbSNP:rs1346044). /FTId=VAR_006906.
keyword 1 - 1432 3D-structure
keyword 1 - 1432 ATP-binding
keyword 1 - 1432 Complete proteome
keyword 1 - 1432 Disease mutation
keyword 1 - 1432 DNA-binding
keyword 1 - 1432 Helicase
keyword 1 - 1432 Hydrolase
keyword 1 - 1432 Nucleotide-binding
keyword 1 - 1432 Nucleus
keyword 1 - 1432 Phosphoprotein
keyword 1 - 1432 Polymorphism
keyword 1 - 1432 Repeat
Molecular Weight 1 - 1432 162495
1 hit 1 - 1432 PF00270
1 hit 1 - 1432 PF00271
1 hit 1 - 1432 PF00570
1 hit 1 - 1432 PF01612
1 hit 1 - 1432 PF09382
1 hit 1 - 1432 PS50967
1 hit 1 - 1432 PS51192
1 hit 1 - 1432 PS51194
false_neg 1 - 1432 PS00690

If you do not find the reagent or information you require, please contact customer.support@lsbio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).


Get Social With Us! Follow us on Facebook Follow us on Google+ Follow us on LinkedIn
Copyright © 2014 LifeSpan BioSciences, Inc. All Rights Reserved Privacy Policy