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Human spleen stained in IHC with Caspase 9 antibody LS-B3741. 
Ask a Question! Our staff of experienced scientists are available to answer your questions about antibodies or immunohistochemistry.
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Recent Publications
Caspase AntibodiesCaspases, or Cysteine Aspartate-specific Proteases, are enzymes involved in the signal transduction pathways of apoptosis and inflammation. Caspases are produced in cells as catalytically inactive zymogens which experience proteolytic processing at conserved aspartic residues. Upon cleavage, they produce a large and a small subunit that dimerize to form the active enzyme. The sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. There are more than 400 caspases so far identified, and they are divided into two major classes: effectors and initiators. |
IHC-plusTM Antibodies ...because seeing is believing!
LSBio's IHC-plusTM antibodies have been tested and identified as being optimal for use in immunohistochemistry (IHC) against formalin-fixed paraffin-embedded (FFPE) human tissues under LSBio's standardized IHC-plus™ protocol. Each antibody is tested at multiple concentrations on more than 20 normal human tissue types, and when appropriate, multiple normal brain regions and/or cancer types. Read more about LSBio's immunohistochemistry (IHC) validation procedure.
Kidney stained in IHC with ACE2 antibody LS-B3197.
Angiotensin converting enzyme 2 (ACE2) is an exopeptidase. Its organ- and cell-specific expression suggest a role in regulation of
cardiovascular and renal function, and fertility.
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Kidney stained in IHC with ATG5 antibody LS-B1843.
Angiotensin converting enzyme 2 (ACE2) is an exopeptidase. Its organ- and cell-specific expression suggest a role in regulation of
cardiovascular and renal function, and fertility.
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Colon, Macrophages stained with CD14 antibody LS-B3012.
CD14 is a monocyte/macrophage marker. It cooperates with other proteins to mediate the innate immune response to bacterial lipopolysaccharide.
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Thymus stained with CD274 antibody LS-B480.
CD274 is highly expressed in heart, skeletal muscle, placenta and lung. It is expressed on activated T- and B-cells, dendritic cells,
keratinocytes and monocytes.
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Heart stained with CD36 antibody LS-B1590.
CD36, a member of the class B scavenger receptor family, may function as a cell adhesion molecule. It is a major platelet glycoprotein,
serving as a receptor for thrombospondin.
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Colon stained in IHC with DKK1 antibody LS-A2867.
DKK1 is a secreted protein which inhibits the WNT signaling pathway. It is associated with the presence of osteolytic bone lesions in multiple myeloma.
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Skin, Hair Follicle stained with FAP antibody LS-A8027.
Fibroblast activation protein alpha (FAP) is expressed on activated stromal fibroblasts in carcinomas. Stromal fibroblasts play a role in
the development, growth and metastasis of carcinomas.
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Liver stained with SLC2A2 antibody LS-B2421. Glucose transporter
GLUT2 (SLC2A2) is an integral membrane glycoprotein of the liver, islet beta cells, intestine, and kidney epithelium. It mediates facilitated
bidirectional glucose transport.
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Liver stained with HP antibody LS-B2266.
Haptoglobin (HP) is secreted from liver. It binds hemoglobin in plasma, preventing loss of iron through the kidneys, protecting them from damage
and making the hemoglobin accessible to degradation.
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Tonsil stained with LAG3 antibody LS-B2237.
Lymphocyte-activation protein 3 (LAG-3, CD223) binds to HLA class-II antigens. It is involved in lymphocyte activation and is found on
activated NK and T-lymphocytes.
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Colon stained with OLFM4 antibody LS-B2055.
Olfactomedin 4 (OLFM4), a marker for the differentiation and progression of gastrointestinal cancers, is highly expressed in pancreatic
cancer, stomach cancer and colon cancer.
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Small Intestine, Vessels stained with OLR1 antibody LS-B2202.
Oxidized low-density lipoprotein receptor 1 (OLR1) binds, internalizes and degrades oxidized low-density lipoprotein and may be involved
in regulation of Fas-induced apoptosis.
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Small Intestine stained with P4HB antibody LS-B2372.
P4HB encodes the beta subunit of prolyl 4-hydroxylase, a highly abundant multifunctional enzyme in the protein disulfide isomerase family.
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Skeletal Muscle stained with RAB7A antibody LS-B1789.
RAB7 is localized to late endosomes and is important in the late endocytic pathway. Defects in RAB7A are the cause of Charcot-Marie-Tooth disease type 2B.
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Testis stained with RORC antibody LS-B1797.
ROR gamma (RORC) is an orphan nuclear receptor. It may be essential for lymphoid organogenesis and may play an important regulatory role in thymopoiesis.
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