VAV1 / VAV

vav 1 guanine nucleotide exchange factor

VAV1 / VAV is a member of the VAV gene family. The VAV proteins are guanine nucleotide exchange factors (GEFs) for Rho family GTPases that activate pathways leading to actin cytoskeletal rearrangements and transcriptional alterations. The encoded protein is important in hematopoiesis, playing a role in T-cell and B-cell development and activation. The encoded protein has been identified as the specific binding partner of Nef proteins from HIV-1. Coexpression and binding of these partners initiates profound morphological changes, cytoskeletal rearrangements and the JNK/SAPK signaling cascade, leading to increased levels of viral transcription and replication. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.

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Products

ELISA Kits (3)

Type

Cell-Based (1)

Cell-Based Phosphorylation (1)

Sandwich (1)

Target

VAV1 / VAV (3)

Reactivity

Human (3)

Mouse (2)

Rat (2)

Format

96-Well Microplate (3)

Publications

No (3)

Sample Type

Adherent Cell Cultures (2)

Cell Lysates (1)

Tissue Homogenates (1)

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Mouse/Human/Rat Phospho-VAV1 / VAV (Tyr174) (Cell-Based Phosphorylation ELISA) ELISA Kit - LS-F1109

Type:

Cell-Based Phosphorylation

Format:

96-Well Microplate

Reactivity:

Mouse, Human, Rat

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Adherent Cell Cultures

Price:

1 Plate/$668

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Mouse/Human/Rat VAV1 / VAV (Cell-Based ELISA) ELISA Kit - LS-F2379

Type:

Cell-Based

Format:

96-Well Microplate

Reactivity:

Mouse, Human, Rat

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Adherent Cell Cultures

Price:

1 Plate/$618

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Human VAV1 / VAV (Sandwich ELISA) ELISA Kit - LS-F74193

Type:

Sandwich

Format:

96-Well Microplate

Reactivity:

Human

Range:

0.156 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Lysates, Tissue Homogenates

Price:

1 Plate/$834

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