Tuberin / TSC2

tuberous sclerosis 2

Tuberous sclerosis complex (TSC) is an autosomal dominant tumor syndrome caused by mutations in either of the TSC1 or TSC2 tumor suppressor genes. The products of these genes form a protein complex that indirectly decreases the signaling of the mammalian Target of Rapamycin (TOR), an evolutionarily conserved serine/threonine kinase that regulates cell growth and cell cycle through its ability to integrate signals from nutrient levels and growth factors. TOR activity is stimulated by Rheb, a member of the Ras superfamily of G-proteins, when the GTP/GDP ratio bound to Rheb is high. Immunoprecipitated TSC1/TSC2 has been shown to stimulate Rheb GTPase activity in vitro, suggesting that the TSC1/TSC2 complex decreases the ability of Rheb to stimulate TOR activity. This is supported by experiments showing that overexpression of TSC1 and TSC2 results in a significant decrease in the GTP/GDP ratio bound to Rheb and the inhibition of cell growth. At least three isoforms of TSC2 exist.

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Products

ELISA Kits (4)

Type

Cell-Based (1)

Cell-Based Phosphorylation (1)

Sandwich (2)

Target

Tuberin / TSC2 (4)

Reactivity

Human (3)

Mouse (3)

Rat (2)

Format

96-Well Microplate (2)

96-Well Strip Plate (2)

Publications

No (4)

Sample Type

Adherent Cell Cultures (2)

Plasma (1)

Serum (1)

Tissue Homogenates (2)

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Human Tuberin / TSC2 (Sandwich ELISA) ELISA Kit - LS-F33459

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

15.625 - 1000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Tissue Homogenates

Price:

1 Plate/$579

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Mouse/Human/Rat Phospho-Tuberin / TSC2 (Ser939) (Cell-Based Phosphorylation ELISA) ELISA Kit - LS-F1233

Type:

Cell-Based Phosphorylation

Format:

96-Well Microplate

Reactivity:

Mouse, Human, Rat

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Adherent Cell Cultures

Price:

1 Plate/$668

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Mouse/Human/Rat Tuberin / TSC2 (Cell-Based ELISA) ELISA Kit - LS-F2369

Type:

Cell-Based

Format:

96-Well Microplate

Reactivity:

Mouse, Human, Rat

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Adherent Cell Cultures

Price:

1 Plate/$534

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Mouse Tuberin / TSC2 (Sandwich ELISA) ELISA Kit - LS-F32093

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Mouse

Range:

15.6 - 1000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$579

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